Applied Neuromuscular PharmacologyB. J. Pollard This book gives a comprehensive and practical review of neuromuscular pharmacology. It covers all aspects of the subject from the discovery and first clinical use of curare, to the newest drugs and latest techniques. Unlike other books on neuromuscular pharmacology, it compares functionalcharacteristics of the drugs in turn - for example, their time of onset and duration of action - rather than simply giving reviews of each group of drugs. This provides you with a thorough understanding on which to base the choice of drugs and techniques in different clinical situations, fromneonates and children to the elderly, and from ambulatory surgery to intensive care. The book also discusses drug interactions with neuromuscular blocking agents, describes techniques for monitoring blockades, and outlines differences in practice between countries. |
Contents
List of contributors | 1 |
The spread of the use of curare in anaesthetic practice | 8 |
Components of the neuromuscular junction | 19 |
Copyright | |
48 other sections not shown
Common terms and phrases
acetylcholine activity adductor pollicis administration anaesthetic Anesthesia and Analgesia Anesthesiology antagonism anticholinesterase appears approximately associated atracurium Bevan binding blockade blood bolus British Journal cardiovascular changes channel cholinesterase clinical compared comparison compounds concentration curare decrease demonstrated depolarizing diaphragm Donati dose doxacurium drug duration of action edrophonium effect elimination et al excretion Feldman Foldes function gallamine given half-life humans increase infants infusion intensive interaction intubation Journal of Anaesthesia less liver measured mechanism mg/kg Miller minutes mivacurium monitoring muscle relaxants muscular neostigmine nerve neuromuscular blocking agents neuromuscular junction nondepolarizing normal observed occur onset pancuronium patients Pharmacokinetics Pharmacology pipecuronium plasma possible potency potential present priming produce prolonged rapid ratio receptor recovery reduced release renal failure reported response result reversal Savarese sensitivity similar stimulation studies succinylcholine suggested surgery surgical suxamethonium Table technique tion transmission tubocurarine vecuronium