The Organic Chemistry of Drug Synthesis, Volume 4
Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
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3-lactam Abstr acetoacetate acetyl acid chloride Acylation adrenergic affords alcohol alkylation amide amino group amoxicillin analogue anhydride anion antagonist antibiotic antidepressant antihypertensive antihypertensive agent Appl aztreonam benzodiazepine benzyl beta bromide carbon carboxyl catalytic cefoperazone cefroxadine cephalosporin Chem Chemistry of Drug chiral Cl Cl Cl clinical CO2Et CO2H CO2Me completes the synthesis compound condensation CONH conjugate addition converted cyclization deblocking derivative displacement Drug Synthesis enol enzyme ester ether formation function halogen heterocyclic hydrogen hydrolysis hydroxyl imidazole imine inhibition inhibitor intermediate involves ketone leads metabolic methyl moiety molecule monobactams nitro group nitrogen NOMe obtained Offen OH OH olefin orally active oxidation phenol piperazine potency prepared primary amine prostaglandin protecting group pyridine pyrimidone reacted reaction reagent receptors reduction removed replaced resulting saponification side chain side effects so,H sodium structural substituted sulfur synthesis begins synthon tion treatment trifluoroacetic acid U.S. Patent