Twins as a tool of behavioral genetics: report of the Dahlem Workshop on What Are the Mechanisms Mediating the Genetic and Environmental Determinants of Behavior? Twins as a Tool of Behavioral Genetics, Berlin 1992, May 17-22
Twins as a Tool of Behavioral Genetics Edited by T. J. Bouchard, Jr. P. Propping Every human being is genetically unique and consequently genetically different from every other human being. The one exception is identical (monozygotic) twins, who share exactly the same genome. Fraternal (dizygotic) twins share half of their genes in common by descent. Twins of both types constitute "an experiment of nature". Because it is unethical to carry out powerful experiments on human beings in order to explore the causes of variation in human traits, this natural experiment with all of its vicissitudes is one of the few windows we have with which to view the genetic and environmental determinants of complex human behavioral traits. Many scientists believe that twins can only be used to estimate "heritability" and that they reveal nothing about how genes influence behavior. In addition, they argue that modern molecular genetics will quickly make twin research obsolete. These widely held views are largely incorrect. Twins are a unique and very powerful tool for exploring a wide variety of hypotheses about both the distal (mostly genetic) and proximal (mostly environmental) origins of human individual differences. Scientific knowledge accumulates most rapidly when scientists ask the right questions and utilize the right tools?the right tools for the job. This book attempts to highlight the questions that might be most productively addressed through the use of twin designs. Every tool, however, has its limitations. This book carefully examines the limitations and assumptions associated with the application of the method to each of the domains discussed. Goal of this Dahlem Workshop: to evaluate the environmental and genetic mechanisms underlying the structure and development of behavior in twins studies: the achievements, limitations, and potentials.
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Natures Twicetold Tale
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What Can Twin Studies Tell Us about the Structure
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adaptive problems adult alcohol analysis approach assessment assortative mating behavioral genetic behavioral geneticists biological Boomsma brain Buss Cardon child childhood co-twins common concordance conduct disorder correlations covariance DeFries depression Devel developmental differential Eaves environmental effects environmental factors environmental influences estimates evolutionary evolutionary psychology extraversion Fulker Galton genes genetic and environmental genetic effects genetic factors genetic influence genetic studies genetic variation genotype Gottesman heritability human important individual differences intelligence interaction linkage Loehlin McGue McGuffin measures methods multiple multivariate MZ and DZ MZ pairs MZ twins neuroticism nonshared environmental parents personality personality psychology phenotype Plomin probands psychiatric disorders Psychol psychology psychopathology quadruplets quantitative genetic risk Rutter sample Schepank schizophrenia scores siblings singletons social specific cognitive abilities strategies structure study of twins T.J. Bouchard trait twin data twin designs twin method twin pairs twin studies twins reared variables variance zygosity