Pathophysiology and Pharmacology of Heart Disease: Proceedings of the Symposium Held by the Indian Section of the International Society for Heart Research, Chandigarh, India, February 1988
Springer, Aug 31, 1989 - Medical - 223 pages
Research at the molecular and the cellular level has greatly enhanced our understanding of the pathogenesis and management of heart disease. Valuable contributions, towards this end, have been made by scientists from different dis ciplines including biochemistry, physiology, pathology, molecular biology and biophysics. We felt that it would be of interest and value to bring together ex perts from diverse specialities to present their work and to discuss the common problems encountered in their endeavours. In accordance, a symposium was organised in February 1988 at the Postgraduate Institute of Medical Education & Research, Chandigarh. It was held during the annual meeting of the Indian section of the International Society for Heart Research. This book is a compila tion of some of the papers presented at the symposium. The symposium was sponsored by the Council on Cardiac Metabolism of the International Society and Federation of Cardiology. A number of Indian or ganisations gave generous financial help. These included the National Academy of Medical Sciences, Indian Council of Medical Research, Council of Scientific and Industrial Research and Department of Science and Technology. Desktop publishing was used to prepare this volume. In doing so we came to appreciate the remarkable qualities, skills and help rendered by Professor Dharam Vir. For typing the manuscripts and for other secretarial assistance we gratefully acknowledge the help of Ravinder and Sawtantar. PATHOPHYSIOLOGY AND PHARMACOLOGY OF HEART DISEASE 1 THE NEWBORN PIG HEART, A SUPERIOR ANIMAL MODEL OF CARDIAC HYPERTROPHY Howard E.
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ATPdependent Caion transport
Transient changes in cyclic AMP and in protein kinase
Calcium and reperfusion damage in heart muscle
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activity adenosine adenylate amrinone animals aorta arrhythmias atherosclerosis ATPase atrial Biochem blood Ca2+ transport calcium channel calmodulin canine cardiac hypertrophy cardiac output Cardiovascular catecholamines cavitation cell membrane cellular cholesterol Circ Res Circulation Clin clinical concentration congestive heart failure contractile coronary artery creatine cyclic AMP cytosolic decrease depression Dhalla NS diabetic diastolic diet dietary drug effect enzyme experimental fatty acids Figure fish oil free radicals function gallopamil GSSG hormone hyponatraemia hypoxia increased induced inhibition inotropic intracellular ISBN ischaemia and reperfusion ischaemic isoproterenol left ventricle left ventricular lesions levels lipid mechanism metabolism milrinone mitochondrial Mol Cell Cardiol monkeys myocardial infarction myocardial ischaemia myocardium nifedipine normal occlusion oedema overload Pathol patients perfused Pharmacol phosphorylation Physiol pigs plasma post-rest potential protein kinase pulmonary rabbit rat heart reduced release renal reperfusion damage role sarcolemma sarcolemmal sarcoplasmic reticulum serum sodium studies subunit superoxide tion tissue ultrasound uptake verapamil