Proteases II: Potential Role in Health and DiseaseWalter H. Hörl, August Heidland The Proceedings of the Second International symposium "Proteases: Potential Role in Health and Disease" which was held in Rothenburg ob der Tauber (FRG) during May 17-20, 1987. The topics discussed those dealing with the physiology and pathophysiology of proteases and their inhibitors, the interactions of proteases and hormones, the kallikrein-Kinin, complement and coagulation system, the function of proteases in arthritis, malignoma, Pancreatitis, intestinal tract, lung and kidney disease as well in hypercatabolic states (acute renal failure, multiple trauma and septicemia). Furthermore some reports dealed with the role of proteases during extracorporeal circulation. The paper presented answered many questions, but reised many more concerning the significance of proteases and their inhibitors in clinical medicine. It was unfortiunately impossible in this volume, to include the extended, lively and stimulating discussions which were enjoyed by the participiants during the conference. The meeting has provided a unique framework for close interaction between scientists from various disciplines, including molecular biology, biology, biochemistry, physiology, surgery, anaesthesiology, endocrinology, hematology, pneumatology and nephrology. |
Contents
INHIBITORS | 1 |
Human Neutral Endopeptidase 24 11 NEP Enkephalinase | 13 |
Structure | 23 |
Copyright | |
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Proteases II: Potential Role in Health and Disease Walter H. Hörl,August Heidland Limited preview - 2012 |
Proteases II: Potential Role in Health and Disease Walter H. Hörl,August Heidland No preview available - 2012 |
Common terms and phrases
a2-macroglobulin acute phase acute renal failure amino acid animals antibodies aprotinin assay Bieth Biochem Biol Biophys blood buffer cancer cathepsin G Chem chymotrypsin Clin clinical collagen complex concentration correlation creatinine culture decreased disease effect Eglin elastin elevated enzyme factor H fractions function glomerular granulocyte Heidland hemodialysis hepatocytes Hörl human increased incubated inhibition injury insulin interleukin-1 intracellular kidney leukocyte elastase leupeptin liver lung lysosomal macrophages metabolism method mice molecular weight monocytes muscle protein neutrophil elastase ng/ml normal pancreatic patients peptide peritonitis Physiol plasma levels plasma membrane plasminogen poly G protease activity protein breakdown protein catabolism protein degradation protein synthesis protein turnover proteinase inhibitor proteolysis proteolytic proteolytic activity proximal tubule pulmonary purified Redl release role sepsis septic serum PSTI significant skeletal muscle SLPI specific stimulated studies substrate supernatants Table tissue trauma uremia uremic rats values vitro vivo