Ergot Alkaloids and Related Compounds

Front Cover
B. Berde, H.O. Schild
Springer Science & Business Media, Dec 6, 2012 - Medical - 1006 pages
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Contents

CHAPTER I
1
CHAPTER II
29
Chemical Modifications in the Lysergic Acid Half of Ergot Alkaloids
38
Substituents
45
Chemical Modification in the Peptide Part of Ergot Alkaloids
61
E Some Analytical Tools for the Determination of Ergot Alkaloids
67
F Subject Index
69
G References
78
PRT 17402
478
Ergocornine
479
Other Ergopeptine Derivatives
484
Serotoninergic Mechanisms
489
DLSD
491
2BrLSD
495
Other Lysergic Acid Derivatives
497
Ergopeptine Derivatives
498

CHAPTER III
87
K Biochemical Identification of Specific Binding Sites for Ergot
191
CHAPTER IV
233
References 3 14
283
CHAPTER V
320
B Hemodynamic Effects
348
Actions on the Heart
371
E Pharmacologic Basis for the Clinical Use of Ergot Alkaloids
387
Venous Thrombosis
389
Shock
390
F References
399
CHAPTER VI
421
B Early Evidence of Central Effects
422
Early Description of Central Effects in Animals
423
The Question of Toxic versus Therapeutic Dose
426
Behavioral Excitation
427
Behavioral Depression
428
Interaction With Centrally Depressant Drugs
430
Anticonvulsant Effects
435
Electroencephalogram
439
Cerebral Blood Flow
448
Body Temperature
453
Emesis
457
Catecholaminergic Mechanisms
461
AgroclavineType Ergot Derivatives
469
Ergometrine
472
DLSD 2BrLSD and Methysergide
475
F Brain Metabolism
500
Adenosine Triphosphate Metabolism in the Brain
503
G References
508
CHAPTER VII
533
Results of Clinical Pharmacology Studies With Ergot Alkaloids
550
E Summary
559
CHAPTER VIII
567
Clinical Applications of LSD
586
E LSD Analogues Tested in Man
590
F CrossTolerance
598
CHAPTER IX
615
B Human Data
659
References
674
CHAPTER X
691
Intact Animals and Men
699
Various Actions of Ergot Alkaloids
710
CHAPTER XI
718
Pharmacokinetics
741
Metabolism
766
E References
796
CHAPTER XII
805
Effects on Reproductive Processes
823
Potential Genetic Effects
833
E Interactions Leading to Enhanced Toxicity
836
Authors Index 853
941
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