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abnormal acid activity acute aerosol agencies airflow airway obstruction Allergy alveolar animals antibody Appl Physiol arterial aspiration assay Association asthma bacteria blood breathing bronchial bronchoconstriction cells changes clearance Clin clinical colonized concentration control subjects COPD correlation creased cystic fibrosis decreased density dependence diagnosis doses drugs dyspnea effect elastase elastin emphysema ethylenediamine expiratory flow exposure figure forced expiratory gentamicin grain workers histamine human hypercapnia hypoxemia increased infections inhalation isoniazid lung volume macrophages maximal mean measured Medical nonsmokers normal subjects obtained oleic acid phenylephrine pneumoniae pneumothorax pressure pulmonary disease pulmonary function PV curve reaction reported RESPIRATORY DISEASE response Rev Respir REVIEW OF RESPIRATORY samples serum significant significantly smoking smooth muscle spirometer streptomycin symptoms theophylline therapy tients tion tissue trypsin tuberculosis tularemia uptake values variability ventilatory vital capacity vitro