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affect the location analysis basic research Bi.tech U.S. Bi.tech biotech plants biotechnology firms biotechnology industry biotechnology research campus cent centers Cetus chemical CHSA City and Regional CMSA concentration data base diagnostic effect Elkington 1985a engineering entirely in academia enzymes established factors firms Daly 1985 Francisco Bay Area Genentech Genetic H.ust.n Herbert Boyer high-tech ibid implications INDUSTRIAL FRONTIER infant industry information technology innovation Institut Pasteur Jersey Kenney Kenney's laboratories Location Quotients major Markusen Massachusetts molecular biology monoclonal Monoclonal Antibodies Monsanto N.n-Metr number of NBFs older firms ottot U.S. P.rtland pattern pharmaceutical Plants Plants Plants Plants T.tal Plants Plants U.S. Bi.tech PMSA processes production protein Protein Engineering question R.chester regional and urban Regional Planning S.uth San Francisco Bay science policy scientific T.tal P.st T.tal Plants Plants T.tal Plants T.tal techniques U.S. T.tal Bi.tech Plants U.S. Bi.tech U.S. United University of California university research urban and regional venture capital Y.rk Yoxen