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absorption acid acidosis activity ADPKD aldosterone ammonium angiotensin apical membrane arterioles basement membrane basolateral membrane bicarbonate Biol biopsy calcium cation cellular chloride clearance Clin clinical collecting tubule concentration convoluted tubule cortex cortical collecting cortical collecting duct creatinine cysts distal tubule effect enzyme excretion Giebisch glomerular capillary glomerular filtration glomeruli gradient hormone hypertension increase inhibition interstitial intracellular Invest Kidney Int loop of Henle lumen luminal mechanism Medicine medulla medullary collecting duct medullary sponge kidney mesangial cells metabolism NaCl Nephrology nephron nephron segments normal organic anions osmolality pathway patients percent perfused peritubular permeability Physiol plasma potassium pressure prostaglandins protein proteinuria proton proximal convoluted tubule proximal tubule rabbit Radiology rat kidney reabsorption receptors renal artery renal disease renal function renal tubules renin role secretion sodium stimulation studies synthesis thick ascending limb tion tissue transepithelial transport uptake urea urinary urine vasa recta vascular vasopressin vesicles