The AdenovirusesHarold S. Ginsberg The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... . |
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Acad activity addition adenovirus DNA adenovirus type Akusjärvi amino acid analysis antigen appears assembly associated binding Biol capsid cells characterization coding complex components contain Continued cores cytoplasmic defective deletion determined DNA replication early early region encoded et al expression fiber FIGURE fragments function gene genetic genome Ginsberg Green hexon human human adenovirus hybrid indicated infected infected cells initiation interaction intermediates isolated late leader Lewis lines located major molecular weight molecules mRNA mutants Natl nucleotide sequence observed organization particles Pettersson Philipson polypeptide position possible precursor present probably Proc promoter properties protein purified recently recombination region residues restriction revealed role serotypes shown similar specific splice stop strands structure studies suggest synthesis terminal transcription transformed translation tumor units viral DNA virion Virol Virology virus viruses vitro Weber