Basic and Systemic Mechanisms of AnesthesiaTakashi Mashimo, Kenji Ogli, Ichiro Uchida This book is constituted of the presentations (symposium, workshop and posters) given at the Seventh International Conference on Molecular and Basic Mechanisms of Anesthesia, held in Nara, Japan during February 2005. During this international event leading researchers presented the latest findings on the mechanisms underlying states of anesthesia. Topics covered included the latest developments in the physico-chemical actions of anesthetics on the membrane, to the molecular identifications such as their receptor-mediated actions. Furthermore, new research was presented on developments in the molecular identification of general anesthetic targets at the receptor level and the functional roles of their molecular targets, revealed by their integration of the in vivo system using genetic engineering techniques. An essential text for all researchers wanting a concise and authoritative overview of current research in the field of mechanisms of anesthesia, this book is a timely update for everyone involved in anesthetic drug development. |
Contents
Molecular mechanisms of general anesthetic action | 3 |
Mechanisms and sites | 21 |
Anesthetic sensitivity is reduced in hippocampal pyramidal neurons from GABAA | 38 |
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Common terms and phrases
2005 Published 5-HT3 receptor activity affinity agonist allosteric amplitude Analg Anesth anesthesia Anesthesiology anesthetic action anesthetic binding B.V. All rights brain calreticulin cells clinical concentrations Corresponding author currents decrease Department of Anesthesiology desensitization domain Drosophila drug E-mail address ELSEVIER ICS www.ics-elsevier.com enflurane enhanced entropy ethanol etomidate excitatory expressed extracellular fatty acids four-a-helix bundle function GABA GABAA receptors GABAergic gating gene glutamate halothane hippocampal hydrophobic increased inhaled anesthetics inhibition inhibitory interactions isoflurane Japan K2p channels ketamine kinetic ligand ligand-gated ion channels lipid mechanism mediated mEPSCs metoclopramide mice mIPSCs modulation molecular mutant nAChRs neurons Neurosci nicotinic acetylcholine receptors NMDA receptor oocytes pathways pentobarbital Pharmacol postsynaptic potassium channels potency potential presynaptic propofol protein Published by Elsevier residues rights reserved sensitivity sevoflurane simulation spinal cord structure studies subunit synaptic syntaxin target thiopental tonic transmembrane volatile anesthetics wild-type Xenopus oocytes