The Biology of TumorsEnrico Mihich, Carlo M. Croce The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het erogeneity of tumor cell populations and tumor cell differentiation, on interactions be tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media tion of gene products. Important methodologies that would allow scientists to measure dif ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu tions and their participation in the spirited discussions that followed. We would also like to thank Drs. |
Contents
THE ROLE FOR ink4a IN MELANOMA PATHOGENESIS One Gene Two Products Multiple Pathways | 1 |
IDENTIFICATION AND CHARACTERIZATION OF COLLABORATING ONCOGENES IN COMPOUND MUTANT MICE | 15 |
THE TRANSCRIPTION FACTOR BMyb IS PHOSPHORYLATED AND ACTIVATED BY CYCLIN ACdk2 | 31 |
DISTINCT DYNAMICS AND REGULATORY SIGNAL TRANSDUCTION OF CELL MIGRATION Lessons from Dendritic Cells Tumor Cells and ... | 43 |
GENOMIC INSTABILITY IN SPORADIC COLORECTAL CANCER A Destabilized Genome Producing Accelerated Cellular Evolution as the Funda... | 51 |
APC AND THE EARLY EVENTS OF COLON CANCER | 57 |
GENOME SCANNING AND GENE DISCOVERY IN BREAST AND OVARIAN CANCER | 65 |
FAILURE OF TUMOR IMMUNITY RESULTING FROM INACCESSIBILITY OF ACTIVATED LYMPHOCYTES TO SOLID TUMORS The Possib... | 73 |
CHARACTERIZATION OF ANTIGENS RECOGNIZED BY T CELLS ON HUMAN TUMORS | 173 |
IDENTIFICATION OF HUMAN TUMOR ANTIGENS USING THE BCELL REPERTOIRE | 185 |
T CELL TOLERANCE VERSUS TUMOR IMMUNITY OR AUTOIMMUNITY | 199 |
MANIPULATION OF T CELL ACTIVATION IN THE ANTITUMOR IMMUNE RESPONSE | 213 |
GENERAL DISCUSSION | 223 |
CYTOKINES AND TUMOR IMMUNOGENICITY Toward an Appropriate Cancer Vaccine | 231 |
TCELL AND NKMEDIATED SURVEILLANCE OF CANCER A Delicate Balancing Act | 249 |
REGULATION OF LEUKOCYTEENDOTHELIAL CELL INTERACTIONS IN TUMOR IMMUNITY | 273 |
DECIPHERING MOLECULAR CIRCUITRY USING HIGHDENSITY DNA ARRAYS | 85 |
USE OF cDNA MICROARRAYS TO ASSESS DNA GENE EXPRESSION PATTERNS IN CANCER | 109 |
EH A NOVEL PROTEIN Protein Interaction Domain | 117 |
DEREGULATION OF CYCLIN D1 IN CANCER | 127 |
DYSREGULATION OF PROGRAMMED CELL DEATH IN CANCER TOWARD A MOLECULAR UNDERSTANDING OF Bcl2 | 145 |
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Common terms and phrases
activation analysis angiogenesis anti-tumor antibodies antigens apoptosis arrays autologous B-Myb Bcl-X₁ binding Biol blood vessels breast cancer cancer cells Cancer Res carcinoma caspases CD8+ cDNA cDNA clone cell cycle cell death cell lines cellular chromosome copy number cyclin D1 cytokines cytotoxic deletion dendritic cells domain effect encoding endothelial cells endothelium epitopes estrogen Forni function gene expression genetic genomic growth factor Hanahan hybridization hyperthermia identified immune response immunogenic Immunol immunotherapy induced inhibition inhibitors ink4a interactions involved Jain L-selectin levels ligand lymphocytes lymphomas mechanisms melanocytes melanoma melanoma cells Melief membrane MHC class Mihich molecular mouse mRNA murine mutations normal oncogene overexpression of cyclin pathway patients peptide phenotype phosphorylation proliferation receptor region regulation role sequence signal transduction similar solid tumors specific studies T-cell target therapy tion tissue transfected transgenic transgenic mice tumor antigens tumor cells vaccines vascular VEGF virus vitro vivo