Pediatric Epilepsy: Diagnosis and TherapyBlaise F. Bourgeois, MD, Edwin Dodson, MD, Douglas R. Nordli, Jr., MD, John M. Pellock, MD, Raman Sankar, MD, PhD The extensively updated third edition of Pediatric Epilepsy: Diagnosis and Therapy continues to be the definitive volume on the diagnosis, treatment, classification, and management of the childhood epilepsies. Written by nearly 100 international leaders in the field, this new edition progresses logically with major sections on the basic mechanisms of the disease, classification, epidemiology, etiology, diagnosis, and age-related syndromes of epilepsy. The core of the new third edition is its completely updated section on antiepileptic drugs, including an in-depth discussion of dosage considerations, drug toxicity, teratogenicity, and drug interactions, with recommendations for optimal combinations when multiple drug therapy is required. Features unique to the third edition include:
|
Contents
Cells Synapses and Circuits | 3 |
2 Ion Channels Membranes and Molecules in Epilepsy and Neuronal Excitability | 31 |
A Neurodevelopmental Perspective | 47 |
4 Metabolic and Pharmacologic Consequences of Seizures | 65 |
5 Neuropathologic Substrates of Epilepsy | 75 |
6 Epileptogenic Cerebral Cortical Malformations | 101 |
7 Genetic Influences on the Risk for Epilepsy | 117 |
8 Classification of Epilepsies in Childhood | 137 |
37 Pharmacokinetic Principles of Antiepileptic Therapy in Children | 503 |
38 Dosage Form Considerations in the Treatment of Pediatric Epilepsy | 515 |
Implications for Treatment with Antiepileptic Drugs | 535 |
40 ACTH and Steroids | 545 |
41 Benzodiazepines | 557 |
42 Carbamazepine and Oxcarbazepine | 567 |
43 Ethosuximide Methsuximide and Trimethadione | 579 |
44 Felbamate | 585 |
9 Epidemiology of Epilepsy in Children | 147 |
10 An Approach to the Child with Paroxysmal Phenomena with Emphasis on Nonepileptic Disorders | 165 |
11 Evaluating the Child with Seizure | 185 |
12 The Use of Electroencephalography in the Diagnosis of Epilepsy in Childhood | 195 |
13 Basics of Neuroimaging in Pediatric Epilepsy | 213 |
14 Neonatal Seizures | 229 |
15 Severe Encephalopathic Epilepsy in Early Infancy | 241 |
Infantile Spasms West Syndrome | 249 |
17 Myoclonic Epilepsies in Infancy and Early Childhood | 269 |
18 Partial Epilepsies in Infancy | 283 |
19 Febrile Seizures | 293 |
20 Generalized Epilepsy with Febrile Seizures Plus GEFS | 303 |
21 LennoxGastaut Syndrome | 307 |
22 Childhood Absence Epilepsies | 323 |
23 Benign Focal Epilepsies of Childhood | 335 |
24 The LandauKleffner Syndrome and Epilepsy with Continuous SpikeWaves during Sleep | 351 |
25 Idiopathic Generalized Epilepsy of Adolescence | 359 |
26 Progressive Myoclonus Epilepsies | 367 |
Simple Partial Seizures Complex Partial Seizures and Rasmussen Syndrome | 377 |
28 Selected Disorders Associated with Epilepsy | 387 |
29 Treatment Decisions in Childhood Seizures | 403 |
30 Comparative Anticonvulsant Profile and Proposed Mechanisms of Action of Antiepileptic Drugs | 413 |
31 EvidenceBased Medicine Issues Related to Drug Selection | 429 |
Monotherapy Versus Polytherapy | 441 |
33 Adverse Effects of Antiepileptic Drugs | 449 |
34 Status Epilepticus and Acute Seizures | 461 |
35 The Female Patient and Epilepsy | 477 |
36 Teratogenic Effects of Antiepileptic Medications | 489 |
45 Gabapentin and Pregabalin | 593 |
46 Lamotrigine | 603 |
47 Levetiracetam | 611 |
48 Barbiturates and Primidone | 621 |
49 Phenytoin and Related Drugs | 639 |
50 Sulthiame | 653 |
51 Tiagabine | 661 |
52 Topiramate | 671 |
53 Valproate | 685 |
54 Vigabatrin | 699 |
55 Vitamins Herbs and Other Alternative Therapies | 711 |
56 Zonisamide | 727 |
57 The Ketogenic Diet | 739 |
58 Inflammation Epilepsy and AntiInflammatory Therapies | 751 |
59 Antiepileptic Drugs in Development | 759 |
60 Surgical Evaluation | 771 |
PETMRI Fusion and Diffusion Tensor Imaging | 785 |
62 Surgical Treatment of TherapyResistant Epilepsy in Children | 791 |
63 Outcome of Epilepsy Surgery in Childhood | 801 |
Use and Effectiveness | 811 |
65 Economics of Pediatric Epilepsy | 831 |
66 Quality of Life in Children with Epilepsy | 837 |
67 Epilepsy Cerebral Palsy and IQ | 847 |
68 Academic Deficits and Interventions in Pediatric Epilepsy | 865 |
69 Cognitive Side Effects of Antiepileptic Drugs | 873 |
883 | |
Other editions - View all
Pediatric Epilepsy: Diagnosis and Therapy Blaise F. Bourgeois, MD,Edwin Dodson, MD,John M. Pellock, MD No preview available - 2007 |
Common terms and phrases
abnormalities absence acid action activity addition adult anticonvulsant antiepileptic drugs appear associated benign brain carbamazepine cause cells cerebral changes channel Chapter Child childhood clinical common complex concentrations convulsions cortical developmental diagnosis discharges disease disorders dose drug early effects epilepsy epileptic et al evidence expression factors febrile seizures Figure findings focal frequently function GABA gene genetic glucose hippocampal human ictal idiopathic important incidence increased induced infantile spasms infants initial interactions Lennox-Gastaut syndrome less levels lobe major malformations mechanisms medication mutations myoclonic neonatal Neurology neurons normal occur onset outcome partial seizures patients pattern Pediatr phenytoin potential present protein rats recent receptor recurrence regions reported response result risk role seen severe sleep slow specific spikes status epilepticus studies subunit suggest syndrome Table temporal therapy tion tonic treated treatment usually valproate