Pediatric Epilepsy: Diagnosis and Therapy

Front Cover
Blaise F. Bourgeois, MD, Edwin Dodson, MD, Douglas R. Nordli, Jr., MD, John M. Pellock, MD, Raman Sankar, MD, PhD
Demos Medical Publishing, Dec 16, 2007 - Medical - 196 pages
The extensively updated third edition of Pediatric Epilepsy: Diagnosis and Therapy continues to be the definitive volume on the diagnosis, treatment, classification, and management of the childhood epilepsies.

Written by nearly 100 international leaders in the field, this new edition progresses logically with major sections on the basic mechanisms of the disease, classification, epidemiology, etiology, diagnosis, and age-related syndromes of epilepsy. The core of the new third edition is its completely updated section on antiepileptic drugs, including an in-depth discussion of dosage considerations, drug toxicity, teratogenicity, and drug interactions, with recommendations for optimal combinations when multiple drug therapy is required.

Features unique to the third edition include:

  • Expanded section on the basic science and mechanism of epilepsy
  • Completely updated drug chapters, including newly released drugs and those in development
  • Expanded chapters on vagus nerve stimulation and surgical treatment
  • Expanded section on co-morbidities

The third edition includes 21 new chapters, including discussions of: epileptic channelopathies; epileptogenic cerebral cortical malformation; epilepsy genes; etiologies and workup; evidence-based medicine issues related to drug selection; Levetiracetam; Sulthiame; Pregabalin; herbal medications; basic and advanced imaging; immunotherapy issues; vagus nerve stimulation therapy; cognitive and psychiatric co-morbidities and educational placement; and psychosocial aspects of epilepsy.

 

Contents

Cells Synapses and Circuits
3
2 Ion Channels Membranes and Molecules in Epilepsy and Neuronal Excitability
31
A Neurodevelopmental Perspective
47
4 Metabolic and Pharmacologic Consequences of Seizures
65
5 Neuropathologic Substrates of Epilepsy
75
6 Epileptogenic Cerebral Cortical Malformations
101
7 Genetic Influences on the Risk for Epilepsy
117
8 Classification of Epilepsies in Childhood
137
37 Pharmacokinetic Principles of Antiepileptic Therapy in Children
503
38 Dosage Form Considerations in the Treatment of Pediatric Epilepsy
515
Implications for Treatment with Antiepileptic Drugs
535
40 ACTH and Steroids
545
41 Benzodiazepines
557
42 Carbamazepine and Oxcarbazepine
567
43 Ethosuximide Methsuximide and Trimethadione
579
44 Felbamate
585

9 Epidemiology of Epilepsy in Children
147
10 An Approach to the Child with Paroxysmal Phenomena with Emphasis on Nonepileptic Disorders
165
11 Evaluating the Child with Seizure
185
12 The Use of Electroencephalography in the Diagnosis of Epilepsy in Childhood
195
13 Basics of Neuroimaging in Pediatric Epilepsy
213
14 Neonatal Seizures
229
15 Severe Encephalopathic Epilepsy in Early Infancy
241
Infantile Spasms West Syndrome
249
17 Myoclonic Epilepsies in Infancy and Early Childhood
269
18 Partial Epilepsies in Infancy
283
19 Febrile Seizures
293
20 Generalized Epilepsy with Febrile Seizures Plus GEFS
303
21 LennoxGastaut Syndrome
307
22 Childhood Absence Epilepsies
323
23 Benign Focal Epilepsies of Childhood
335
24 The LandauKleffner Syndrome and Epilepsy with Continuous SpikeWaves during Sleep
351
25 Idiopathic Generalized Epilepsy of Adolescence
359
26 Progressive Myoclonus Epilepsies
367
Simple Partial Seizures Complex Partial Seizures and Rasmussen Syndrome
377
28 Selected Disorders Associated with Epilepsy
387
29 Treatment Decisions in Childhood Seizures
403
30 Comparative Anticonvulsant Profile and Proposed Mechanisms of Action of Antiepileptic Drugs
413
31 EvidenceBased Medicine Issues Related to Drug Selection
429
Monotherapy Versus Polytherapy
441
33 Adverse Effects of Antiepileptic Drugs
449
34 Status Epilepticus and Acute Seizures
461
35 The Female Patient and Epilepsy
477
36 Teratogenic Effects of Antiepileptic Medications
489
45 Gabapentin and Pregabalin
593
46 Lamotrigine
603
47 Levetiracetam
611
48 Barbiturates and Primidone
621
49 Phenytoin and Related Drugs
639
50 Sulthiame
653
51 Tiagabine
661
52 Topiramate
671
53 Valproate
685
54 Vigabatrin
699
55 Vitamins Herbs and Other Alternative Therapies
711
56 Zonisamide
727
57 The Ketogenic Diet
739
58 Inflammation Epilepsy and AntiInflammatory Therapies
751
59 Antiepileptic Drugs in Development
759
60 Surgical Evaluation
771
PETMRI Fusion and Diffusion Tensor Imaging
785
62 Surgical Treatment of TherapyResistant Epilepsy in Children
791
63 Outcome of Epilepsy Surgery in Childhood
801
Use and Effectiveness
811
65 Economics of Pediatric Epilepsy
831
66 Quality of Life in Children with Epilepsy
837
67 Epilepsy Cerebral Palsy and IQ
847
68 Academic Deficits and Interventions in Pediatric Epilepsy
865
69 Cognitive Side Effects of Antiepileptic Drugs
873
Index
883
Copyright

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About the author (2007)

Blaise F.D. Bourgeois, MD is Professor of Neurology at Harvard Medical School, and Director of the Division of Epilepsy and Clinical Neurophysiology at Children's Hospital Boston

Edwin Dodson, MD, is Associate Vice Chancellor and Associate Dean for Admissions and Continuing Medical Education and Professor of Pediatrics and Neurology at the Washington University School of Medicine.

Douglas R. Nordli, Jr., MD, is the Lorna S. and James P. Langdon Chair of Pediatric Epilepsy at Northwestern University School of Medicine and Director, Children's Memorial Epilepsy Center at Children's Memorial Hospital.

John M. Pellock, MD, is Chairman of the Division of Child Neurology, Vice Chairman of the Department of Neurology and Professor of Neurology, Pediatrics, Pharmacy and Pharmaceutics at the Medical College of Virginia, Virginia Commonwealth University Health System, in Richmond, Virginia.

Raman Sankar, MD, PhD, is Professor and Chief of Pediatric Neurology and Rubin Brown Distinguished Chair at David Geffen School of Medicine at UCLA.

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