Cancer Metastasis: Biologic Basis and Therapeutics

Front Cover
David Lyden, Danny R. Welch, Bethan Psaila
Cambridge University Press, Apr 25, 2011 - Science
Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.
 

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An excellent and comprehensive overview of cancer metastasis covering all aspects from very basic molecular biology to therapeutic approaches.

Contents

MODELS AND TOOLS FOR METASTASIS STUDIES
5
Genetic Models for Cancer Metastasis
15
Computational Models
25
Intravital Microscopy to Visualize Invasion and Metastasis
40
GENES
55
The Role of Metastasis Suppressor Genes in Metastasis
64
StromalDerived Factors That Dictate OrganSpecific Metastasis
77
Epigenetics
85
Therapeutic Approaches for Metastatic
313
Gastric Cancer Metastasis
325
Metastatic Pancreatic Cancer
333
Metastasis of Primary Liver Cancer
344
Advances in Management of Metastatic Colorectal Cancer
356
Lung Cancer Metastasis
369
Evaluation and Treatment
382
Bladder Cancer
395

Germline Variation and Other Host Determinants of Metastatic
96
VARIOUS PROPERTIES OF CANCER CELLS
117
Apoptosis Anoikis and Senescence
131
Metastatic Inefficiency and Tumor Dormancy
148
STROMAL CELLSEXTRACELLULAR MATRIX
155
Proteolytic Cascades in Invasion and Metastasis
167
Role of Matrix Metalloproteinases in Tumor Invasion and Metastasis
183
CellDerived Microvesicles and Metastasis
191
SYSTEMIC FACTORS
199
Determinants of OrganSpecific Metastasis
215
Function and Expression of the uPAuPAR System in Cancer Metastasis
223
On the Route to Cancer Metastasis
237
CLINICAL RESEARCH
255
Neuroblastoma
264
Retinoblastoma
278
Primary Brain Tumors and Cerebral Metastases
282
Head and Neck Cancer Metastasis
294
Bone Complications of Myeloma and Lymphoma
417
Breast Metastasis
425
Gynecologic Malignancies
440
Thoughts on Biology and Therapeutics
456
The Biology and Treatment of Metastatic Testicular Cancer
465
Applications of Proteomics to Metastasis Diagnosis and Individualized
475
Critical Issues of Research on Circulating and Disseminated Tumor Cells
486
Lymphatic Mapping and Sentinel Lymph Node Biopsy
501
Molecular Imaging and Metastasis
516
Preserving Bone Health in Malignancy and Complications
538
Role of Platelets and Thrombin in Metastasis
552
THERAPIES
563
Immunotherapy
587
Discovery and Development of Drugs Targeting Tumor Invasion
600
The Role of Radiotherapy in the Treatment of Metastatic Disease
612
Prospects for Clinical Trials of Metastasis Inhibitors
622
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About the author (2011)

David Lyden is the Stavros S. Niarchos Associate Professor in Pediatrics and Cell and Developmental Biology at the Children's Cancer and Blood Foundation Laboratories at Weill Cornell Medical College. He is a Neuro-oncologist at Memorial Sloan-Kettering Cancer Center. Also, Dr Lyden is an Investigator of the Champalimaud Foundation, the first research, prevention and treatment center for metastatic disease. In 2007, he received the Presidential Medical Distinction Award from President Cavaco Silva of Portugal.

Danny R. Welch is Leonard H. Robinson Professor of Pathology at the University of Alabama, Birmingham. He actively holds numerous titles in various organizations, such as Co-Chair of the Program and Education Committees of American Association of Cancer Research, editor-in-chief of Clinical and Experimental Metastasis, and Chair of the Cancer Genetics Study Section at the National Institute of Health. Dr Welch has published six books and holds five patents.

Bethan Psaila is a Research Fellow at Imperial College of Medicine in London and Weill Cornell Medical College of New York. Dr Psaila is the recipient of a Fulbright Scholarship in Cancer Research and a Kay Kendall Leukaemia Fund Travelling Fellowship.

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