Cancer Metastasis: Biologic Basis and Therapeutics

David Lyden, Danny R. Welch, Bethan Psaila

Cambridge University Press, Apr 25, 2011 - Science

Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.

Contents

• MODELS AND TOOLS FOR METASTASIS STUDIES: 5
• Genetic Models for Cancer Metastasis: 15
• Computational Models: 25
• Intravital Microscopy to Visualize Invasion and Metastasis: 40
• GENES: 55
• The Role of Metastasis Suppressor Genes in Metastasis: 64
• StromalDerived Factors That Dictate OrganSpecific Metastasis: 77
• Epigenetics: 85
• Germline Variation and Other Host Determinants of Metastatic: 96
• VARIOUS PROPERTIES OF CANCER CELLS: 117
• Apoptosis Anoikis and Senescence: 131
• Metastatic Inefficiency and Tumor Dormancy: 148
• STROMAL CELLSEXTRACELLULAR MATRIX: 155
• Proteolytic Cascades in Invasion and Metastasis: 167
• Role of Matrix Metalloproteinases in Tumor Invasion and Metastasis: 183
• CellDerived Microvesicles and Metastasis: 191
• SYSTEMIC FACTORS: 199
• Determinants of OrganSpecific Metastasis: 215
• Function and Expression of the uPAuPAR System in Cancer Metastasis: 223
• On the Route to Cancer Metastasis: 237
• CLINICAL RESEARCH: 255
• Neuroblastoma: 264
• Retinoblastoma: 278
• Primary Brain Tumors and Cerebral Metastases: 282
• Head and Neck Cancer Metastasis: 294
• Therapeutic Approaches for Metastatic: 313
• Gastric Cancer Metastasis: 325
• Metastatic Pancreatic Cancer: 333
• Metastasis of Primary Liver Cancer: 344
• Advances in Management of Metastatic Colorectal Cancer: 356
• Lung Cancer Metastasis: 369
• Evaluation and Treatment: 382
• Bladder Cancer: 395
• Bone Complications of Myeloma and Lymphoma: 417
• Breast Metastasis: 425
• Gynecologic Malignancies: 440
• Thoughts on Biology and Therapeutics: 456
• The Biology and Treatment of Metastatic Testicular Cancer: 465
• Applications of Proteomics to Metastasis Diagnosis and Individualized: 475
• Critical Issues of Research on Circulating and Disseminated Tumor Cells: 486
• Molecular Imaging and Metastasis: 516
• Preserving Bone Health in Malignancy and Complications: 538
• Role of Platelets and Thrombin in Metastasis: 552
• THERAPIES: 563
• Immunotherapy: 587
• Discovery and Development of Drugs Targeting Tumor Invasion: 600
• The Role of Radiotherapy in the Treatment of Metastatic Disease: 612
• Prospects for Clinical Trials of Metastasis Inhibitors: 622

About the author

David Lyden is the Stavros S. Niarchos Associate Professor in Pediatrics and Cell and Developmental Biology at the Children's Cancer and Blood Foundation Laboratories at Weill Cornell Medical College. He is a Neuro-oncologist at Memorial Sloan-Kettering Cancer Center. Also, Dr Lyden is an Investigator of the Champalimaud Foundation, the first research, prevention and treatment center for metastatic disease. In 2007, he received the Presidential Medical Distinction Award from President Cavaco Silva of Portugal.

Danny R. Welch is Leonard H. Robinson Professor of Pathology at the University of Alabama, Birmingham. He actively holds numerous titles in various organizations, such as Co-Chair of the Program and Education Committees of American Association of Cancer Research, editor-in-chief of Clinical and Experimental Metastasis, and Chair of the Cancer Genetics Study Section at the National Institute of Health. Dr Welch has published six books and holds five patents.

Bethan Psaila is a Research Fellow at Imperial College of Medicine in London and Weill Cornell Medical College of New York. Dr Psaila is the recipient of a Fulbright Scholarship in Cancer Research and a Kay Kendall Leukaemia Fund Travelling Fellowship.

Bibliographic information

• Title: Cancer Metastasis: Biologic Basis and Therapeutics
• Editors: David Lyden, Danny R. Welch, Bethan Psaila
• Publisher: Cambridge University Press, 2011
• ISBN: 1139498754, 9781139498753
• Subjects: Medical / Oncology / General; Science / Life Sciences / Developmental Biology