All-fiber Endoscopic Optical Imaging Devices
Optical coherence tomography (OCT) is an emerging imaging modality that is capable of providing noninvasive, subsurface optical imaging of biological tissues with micron-scale resolution. The operation of an OCT system is based on the principle of interferometry, which uses the low coherence interference between a reference and a signal beam derived from a broadband optical source. It can be used to generate slice images of three-dimensional objects at a resolution level much greater than that currently available using MRI, CT scan, or ultrasound scans. One of the goals of this dissertation is to design and test a compact all-fiber Fourier Domain Optical Coherence Tomography (FD-OCT) system based on a common-path interferometer configuration, to develop the software algorithms necessary to acquire cross-sectional biological tissue images at high refresh rates, to provide various scanning approaches for the fiber optic probes and to optimize and analyze the system sensitivity for various specific applications.
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Basic Fiber Optics
Optical Coherence Tomography
OCT System and Results
Endoscopic Fiber Confocal Microscopy with a GRIN Lens
acquired signal Airy disk angle axial resolution axial scan balanced detection bandwidth beam splitter beat noise biological tissues coherence length confocal effect confocal image confocal microscope confocal slicing depth detector dissertation distance endoscopic Equation experimental FD-OCT system Fiber Confocal Microscope fiber optic focal plane Fourier domain Fourier Domain OCT Fourier transformed Frame frequency function FWHM Gaussian glass slide GRIN lens high resolution intensity interface interference interferometer design laser lateral resolution lenses light source measured Michelson interferometer mirror modulations objective lens obtained OCT imaging optic axis Optical Coherence Tomography optical fiber Outer parameters Path OCT photocurrent photon noise pixel polarization probe propagation reference and sample reference arm reference reflectivity reference signal refractive index Sagnac interferometer sample arm sample signal scanning stage scattering sensitivity shown in Figure single mode fiber source power spatial specimen spectral spectrometer sub-cellular transverse resolution waveguide wavelength wide-field microscope