Metallo-Drugs: Development and Action of Anticancer Agents

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Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel
Walter de Gruyter GmbH & Co KG, Feb 5, 2018 - Science - 588 pages

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

 

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Contents

Our Current Understanding of Their Actions
1
2 Polynuclear Platinum Complexes Structural Diversity and DNA Binding
43
3 PlatinumIV Prodrugs
69
4 Metalloglycomics
109
5 The Deceptively Similar RutheniumIII Drug Candidates KP1019 and NAMIA Have Different Actions What Did We Learn in the Past 30 Years?
141
6 Multinuclear Organometallic RutheniumArene Complexes for Cancer Therapy
171
7 Medicinal Chemistry of Gold Anticancer Metallodrugs
199
8 Coordination Complexes of TitaniumIV for Anticancer Therapy
219
Using Shape to Target DNA and RNA Junctions and Other Nucleic Acid Structures
303
12 Nucleic Acid Quadruplexes and MetalloDrugs
325
13 Antitumor Metallodrugs that Target Proteins
351
Structural Requirements for DNA Recognition and Anticancer Activity
387
A DoubleEdged Sword
437
16 Copper Complexes in Cancer Therapy
469
17 Targeting ZincII Signalling to Prevent Cancer
507
Subject Index
531

9 Health Benefits of Vanadium and Its Potential as an Anticancer Agent
251
10 Gallium Complexes as Anticancer Drugs
281

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About the author (2018)

Helmut and Astrid Sigel, University of Basel, Switzerland; Roland K. O. Sigel and Eva Freisinger, University of Zürich, Switzerland.

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