Vitamin C in Health and Disease

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CRC Press, May 5, 1997 - Medical - 560 pages
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"Provides an up-to-the-minute, comprehensive analysis of the most recent theoretical and clinical developments in vitamin C research--integrating a wide variety of interdisciplinary studies into a single-source volume. Highlights the redox properties of vitamin C, including regeneration, participation in antioxidant networks, and influence on atherosclerosis."
 

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Contents

A History of Scurvy and Vitamin C
1
CHEMISTRY AND BIOCHEMISTRY
25
Antioxidant and Prooxidant Properties of Vitamin C
59
The Vitamin C Radical and Its Reactions
75
Vitamin C and Redox Cycling Antioxidants
95
Regeneration of Vitamin C
109
Protein Glycation by the Oxidation Products of Ascorbic Acid
123
Ascorbate Membrane Transport Properties
143
Effect of Vitamin C on Leukocyte Function and Adhesion
295
Mechanisms Underlying the Action of Vitamin C in Viral
309
Blood Vitamin C in Human Glucose6Phosphate Dehydrogenase
323
Vitamin C in Cutaneous Biology
333
Human Metabolism and the Requirement for Vitamin C
341
Vitamin C Safety in Humans
367
Vitamin C in Prospective Epidemiological Studies
381
Nitrogen Oxides Are Important Contributors to Cigarette SmokeInduced
399

Mechanisms of Action
163
Protection of Human LowDensity Lipoprotein from Oxidative
183
The Importance of Ascorbate as
193
Vitamin C Collagen Biosynthesis and Aging
205
Oxidative Stress and Ascorbate in Relation to Risk for Cataract
231
Antioxidant Action of Vitamin C in the Lung
265
Vitamin C and Asthma
279
Vitamin C and Cigarette Smoke Exposure
413
Vitamin C Smoking and Alcohol Consumption
425
Vitamin C and Infectious Diseases
471
Ascorbic Acid and Periodontal Disease
505
Topical Vitamin C
517
Index
525
Copyright

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Page 8 - The consequence was, that the most sudden and visible good effects were perceived from the use of the oranges and lemons ; one of those who had taken them, being at the end of six days fit for duty.
Page 467 - Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA.
Page 136 - The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin dependent diabetes mellitus.
Page 467 - Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.
Page 179 - Autoxidation of lipids and antioxidation by a-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein.
Page 422 - Crystal RG. Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.
Page 178 - Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J. Clin. Invest.
Page 177 - Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 1987;84:2995-98.
Page 176 - Henriksen T, Mahoney EM. Steinberg D, Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.
Page 179 - STEINBERG, D.: Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

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