Prostaglandins and Their Inhibitors in Clinical Obstetrics and GynaecologyM. Bygdeman, Gary Berger, L.G. Keith It is clear today that several prostaglandins play an important role in the regulation of many of the physiological events of the reproductive organs in the human. Both naturally occurring prostaglandins and their analogues are used routinely in many countries to ripen the cervix and induce labour at term as well as to dilate the cervix and to terminate pregnancy. Prostaglandin biosynthesis inhibitors are widely used in the treatment of primary dysmenorrhoea. The editors have aimed at an accurate, thorough, yet easily under standable review of the status in 1986 of medical knowledge regarding both the physiological importance and the clinical use of prostaglan dins and their inhibitors in obstetrics and gynaecology. I believe this book will be of value for all clinicians concerned with reproductive health. The list of authors guarantees an authoritative and up-to-date review of this active field. SUNE BERGSTROM Karolinska Institutet, Stockholm, Sweden Table Examples of clinical use of natural prostaglandins and some prostaglandin analogues Indications Prostaglandin Route of administration Manufacturer Dilatation of the cervix prior 15-methyl-PGF • Intramuscular Upjohn, USA 2 to vacuum aspiration 16-phenoxy-PGE methyl sulphonylamide Intramuscular Schering AG, West Germany 2 16,16-dimethyl-PGE methyl ester 1 Vaginal ONO, Japan; May & Baker, UK Second trimester abortion Intra -amniotic Upjohn, USA; ONO, Japan PGF 20 Upjohn, USA PGE Vaginal 2 Upjohn, USA 15-methyl-PGF 2. |
From inside the book
Results 1-3 of 60
Page 154
... prosta- glandin F2 . , on the other hand , seems less abundant . 2 Two studies have suggested that prostaglandin E , is the dominant influence in early labour , whereas prostaglandin F2 , dominates as labour progresses 32,33 . If this ...
... prosta- glandin F2 . , on the other hand , seems less abundant . 2 Two studies have suggested that prostaglandin E , is the dominant influence in early labour , whereas prostaglandin F2 , dominates as labour progresses 32,33 . If this ...
Page 274
... prosta- glandin directly to the target organ , the myometrium , would enhance the myometrial effects while reducing the systemic absorption of pros- taglandin , and therefore minimizing side - effects . Extra - amniotic ad- ministration ...
... prosta- glandin directly to the target organ , the myometrium , would enhance the myometrial effects while reducing the systemic absorption of pros- taglandin , and therefore minimizing side - effects . Extra - amniotic ad- ministration ...
Page 285
... prosta- glandin treated patients was an increase of 4.2 mm and , as previously noted , the maximum cervical change occurred at 4-5 h following pros- taglandin administration . The cervical dilatory effects of the prosta- glandins were ...
... prosta- glandin treated patients was an increase of 4.2 mm and , as previously noted , the maximum cervical change occurred at 4-5 h following pros- taglandin administration . The cervical dilatory effects of the prosta- glandins were ...
Contents
Bioregulation and mode of action | 3 |
Structure biosynthesis and metabolism | 13 |
The cervix | 29 |
Copyright | |
14 other sections not shown
Other editions - View all
Prostaglandins and their Inhibitors in Clinical Obstetrics and Gynaecology M. Bygdeman,G. Berger,L.G. Keith No preview available - 2012 |
Prostaglandins and Their Inhibitors in Clinical Obstetrics and Gynaecology M. Bygdeman,G. Berger,L. G. Keith No preview available - 1986 |
Common terms and phrases
abortifacient Acta Obstet amniotic amniotomy analogues arachidonic acid arteries Biol biosynthesis blastocyst blood loss Bygdeman cells cervical dilatation cervical ripening Clin clinical collagen compounds concentrations contractility dose drugs dysmenorrhoea effect endometrial endometriosis endometrium Fertil fetal fetus fluid gastrointestinal side-effects gestation glandin Gynecol hormones human hypertensive hypertonia i.v. oxytocin implantation increase indomethacin induction of labour infertility infusion inhibition injection intra-amniotic intramuscular intrauterine intravenous Karim labour induction Lancet Lauersen levels luteal maternal menstrual metabolism midtrimester abortion myometrial myometrium naproxen non-pregnant normal oestrogen oral ovarian ovulation ovum transport oxytocin patients PGE2 PGF2 PGSI placental plasma platelet postpartum pregnancy production progesterone prosta prostacyclin prostaglan prostaglandin F2 prostaglandin synthesis prostaglandin synthetase rabbit Reprod response ritodrine role Scand second trimester smooth muscle stimulation studies sulprostone suppositories symptoms taglandin therapy thromboxane tion tissue tocolysis tocolytic treatment Ulmsten uterine uterine contractions uterine hypertonia uterus vaginal vitro Wiqvist women