Casarett & Doull's Toxicology: The Basic Science of Poisons, Seventh Edition
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Page 32
... studies not only characterize the dose–response relationship of a test substance after repeated administration but also provide data for a more reasonable prediction of appropriate doses for chronic exposure studies. For chemicals that ...
... studies not only characterize the dose–response relationship of a test substance after repeated administration but also provide data for a more reasonable prediction of appropriate doses for chronic exposure studies. For chemicals that ...
Page 1132
... studies used to develop the 1987 PM10 NAAQS, there were more than thirty studies for the 1997 revision and the promulgation of the new index, PM2.5 NAAQS [15 μg/m3, annual mean; 65 μg/m3 daily maximum for PM of diameter <2.5 μm (PM2.5)] ...
... studies used to develop the 1987 PM10 NAAQS, there were more than thirty studies for the 1997 revision and the promulgation of the new index, PM2.5 NAAQS [15 μg/m3, annual mean; 65 μg/m3 daily maximum for PM of diameter <2.5 μm (PM2.5)] ...
Page 1285
... Studies and Experimental Exposure Studies observational epidemiologic studies Reflects true exposure among population at risk Complex and variable in space and time May include nonoccupational exposures to toxicant or related compounds ...
... Studies and Experimental Exposure Studies observational epidemiologic studies Reflects true exposure among population at risk Complex and variable in space and time May include nonoccupational exposures to toxicant or related compounds ...
Contents
Unit 2 Disposition of Toxicants | 129 |
Unit 3 NonOrganDirected Toxicity | 327 |
Unit 4 Target Organ Toxicity | 453 |
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absorption acid activity addition agents alterations animals appears aromatic assays associated binding blood cancer carcinogens catalyzed cause cells cellular changes chemical chromosome compartment compounds concentration conjugation contain cytochrome P450 damage decrease detected determined developmental differences dose drugs effects elimination enzymes et al evaluation example excretion exposure expression factors Figure formation function gene genetic glucuronide glutathione growth half-life Health human important increased individuals induced inhibition inhibitors initial interactions involved known lead levels liver lung major mechanisms membrane metabolism metabolites mice molecules mouse mutagenic mutations normal observed occur organ oxidase oxidative oxygen pathway Pharmacol placenta plasma potential produce proteins rats reactions reactive receptor reduction relatively repair response risk risk assessment role shown signaling species structure studies substrates Table tion tissue toxicity Toxicol toxicology transport tumor vitro whereas xenobiotics