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5-vinyl-OZT Acta activity aflatoxin aglucon products aglycones alfalfa alfalfa saponins Allergy amino acids animals autoxidized Biochem Biol Biophys Birk blood Boatner carcinogenic caused cells Chem chemical chicks chymotrypsin compounds concentration containing cottonseed meal cottonseed oil cyanide Daxenbichler diet effect enzyme erythrocytes experimental extracts fatty acids favism feeding Food Agric food allergens Food Chem fraction free gossypol G6PD glucosinolates gossypol gossypol pigments gossypurpurin growth heat human hydrolysis ingestion inhibited intestinal isolated Jaffe Kakade Kjaer Kunitz lectins legumes Liener lipid liver Lyman medicagenic acid metabolism methionine methods molecular weight Nature London nitriles Nutr ODAP Oil Chem oxidation pancreatic Phaseolus Physiol Phytochemistry plant Poult Proc processing protease inhibitors protein rapeseed rapeseed meal rats raw soybeans reaction reported residues Ryan saponins sativus seed meal Sohonie species studies symptoms thiocyanate thioglucosidase thyroid tion toxic trypsin inhibitor VanEtten varieties