Muscle Aging, Inclusion-Body Myositis and Myopathies

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Valerie Askanas, W. King Engel
John Wiley & Sons, Feb 27, 2012 - Medical - 250 pages
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The aging of society is leading to many challenges across all areas of medicine. The problems of muscle aging have led to a rise in the incidence of less common conditions, which though not terminal are debilitating and frequently progressive, and often underdiagnosed or misdiagnosed. Written by a team of international experts, this landmark book will look at the general clinical problems associated with muscle aging before examining inclusion-body myositis and myopathies, a group of the more important diseases of muscle aging. With case vignettes to aid diagnosis to ensure correct management of an illness, here is an essential reference for professionals and students.
 

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Contents

pathological aspects
3
clinical considerations
33
patient vignettes
55
Mitochondrial changes in aging with particular reference to muscle and possible
81
relevance to
89
role of aging
111
Inflammatory and autoimmune features of inclusionbody myositis
146
clinical symptoms physical findings
159
Pathologic diagnostic criteria of sporadic inclusionbody myositis and hereditary
168
Function and mutations of the GNE gene leading to distal myopathy with rimmed
177
GNE myopathy hereditary inclusionbody myopathydistal myopathy with
191
Department of Neuroscience New York NY
199
Function and structure of VCP mutations leading to inclusionbody myopathy
206
Department of Developmental Neurobiology University of Utah
230
Index
241
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About the author (2012)

Edited by 
Valerie Askanas, MD, PhD, Departments  of Neurology andPathology, University of Southern California, Keck School ofMedicine, CA, USA
  
W. King Engel, MD, Departments  of Neurology andPathology, University of Southern California, Keck School ofMedicine, CA, USA  

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