Biosafety in Industrial BiotechnologyP. Hambleton, T. Salusbury As an industry, biotechnology may be likened to the Hymn Book, being both ancient and modern. Whereas activities such as baking, brewing, the fermenting of foods date from our earliest attempts to control and utilise the environment, the application of recombinant DNA technology is recognised as being at the forefront of novel industrial development. Perhaps because of its association with processing foodstuffs together with the benefits derived from applications in the early organic chemistry and pharmaceutical industries, biotechnology has been regarded as being inherently safe. Yet unlike other modern industries, such as chemical and nuclear, where regulation has followed from incidents or accidents, modern biotechnology has been subject to close scrutiny and regulation almost from its inception. The process of regulation itself is somewhat unusual in that it was initially self-imposed by the very scientists who developed the fundamental techniques of recombinant DNA technology. They recognised the signific ance of their development but were concerned of the effects on humans and the environment of uncontrolled application of the new, powerful technology. Concern about the possible consequences of genetic manipula tion has undoubtedly been the driving force behind the regulations that are now in place in many parts of the world and which are the subject of this book. Safety issues in the biotechnology industry can be categorised under three headings: worker, environmental and consumer (product) safety. |
Contents
| 1 | |
| 3 | |
| 6 | |
Disclaimer | 13 |
443 | 43 |
Acknowledgements | 66 |
14 | 70 |
66 | 86 |
Containment of unit processes | 129 |
Other editions - View all
Common terms and phrases
aerosol Agency Agriculture airborne allergenic animal application approval bacteria biocide biological Biological containment bioprocessing bioreactor Biosafety Biosafety Level biotechnology products cabinets cell disruption centrifuge chemical concentration containment level decontamination deliberate release device discharge drug effective effluent endotoxin ensure environment Environmental Protection enzyme equipment exposure facilities factories Federal fermentation filter food additive freeze-drier gene genetically modified micro-organisms Genetically Modified Organisms genetically-modified organisms GMMOs GMOs guidance guidelines Hambleton hazards health and safety HMSO industry Kirishi laboratory legislation liquid MAFF manufacturing material methods micro-organisms microbiological Ministry Monbusho notification OECD operation particles pathogens pesticides pharmaceutical plant potential pressure prevent procedures pump r-DNA technology Recombinant DNA regulations regulatory reported risk assessment safe sampler sampling seal Single cell protein Soviet specific stage steam sterilisation substance techniques testing USSR vaccines valve vials workers