New Experimental Modalities in the Control of NeoplasiaPrakash Chandra Acquisition of new knowledge about the biological and bio chemical nature of neoplastic cells has led to the design and development of several experimental approaches in the tre&tment of cancer. These approaches emerge from the recent work in tu mor virology, e. g. the control of vital cellular genes by viral regulatory signals; the implication of monoclonal antibodies as a vehicle for the targeted drug delivery and selective de struction of tumor cells; immunologic advances in the recog nition of some specific events during metastatic growth; the role of biological response modifiers in modifying or rever sing malignant growth; and biochemical advances, such as the role of gene amplification in drug resistance and the app roaches to the reversal of resistance in drug refractory cancer, the role of membranes in designing useful strategies, the identification of new enzymic targets in some types of cancer cells, and the characterization of metabolically active forms of cytostatic compounds. These are the important issues which were addressed in an international NATO Advanced Study Institute (ASI) attended by scientists from allover the world representing a wide spectrum of scientific disciplines. Although the acquired immune deficiency syndrome (AIDS) is not a malignant disease, but the etiological involvement of a retrovirus belonging to the family of human T-cell lympho tropic viruses which cause leukemia and lymphomas in man, justifies its inclusion in the agenda of this Study Institute. Scientific presentations from Drs. |
Contents
Acquisition of Metastatic Properties via Somatic | 41 |
Oncogenes and Tyrosine Kinase Activities as | 57 |
6 | 81 |
Monoclonal Antibody Targeting of AntiCancer | 91 |
Human Monoclonal Antibodies Directed Against | 123 |
11 | 131 |
Recent Advances in Thymic Hormone Research | 137 |
TCell Growth Factor Interleukin | 165 |
Antitumor Activity Pharmacology and Clinical | 235 |
Therapeutic Efficacy of Oxazaphosphorines | 243 |
H Zur Hausen and E M de Villiers | 255 |
Associated Cancers | 263 |
Bovine Leukosis Virus as a Model for Human | 279 |
23 | 285 |
Molecular Biology of the Human TLymphotropic | 293 |
Inhibition of HTLVIII Replication | 329 |
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A. L. Goldstein Acad acid activity AIDS Anders anti-idiotype antigen assay Biochem biological blood c-src Cancer Res carcinoma cell lines cellular chromosome clinical clones crosslinked culture cyclophosphamide cytotoxic detected differentiation disease DNA polymerase dose drug EB virus effect enzyme expression function genome growth factor high metastatic HTLV HTLV-I HTLV-III HTLV-III/LAV human T-cell HuMTV hybridoma hybrids IL-2 gene immune immunodeficiency Immunol immunological induced infected inhibition inhibitors interferon interleukin-2 Kaposi's sarcoma kinase leukemia levels liver lymphocytes lymphokine lymphoma malignant melanoma membrane metastatic methotrexate mice molecular monoclonal antibodies mouse murine Natl neoplasia normal oncogenes patients peptides phenotype Proc production protein R.C. Gallo receptor replication resistance retroviruses reverse transcriptase sarcoma sequence serum specific spleen studies syndrome T-cell target thymic factor thymic hormones thymopoietin thymosin thymus tissue transferase transformation treatment tumor tumor cells viral viruses vitro vivo Wong-Staal Xiphophorus