Adult Neurogenesis

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CSHL Press, 2008 - Medical - 673 pages
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The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies.
Adult Neurogenesisincludes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

 

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Great resource for any lab interested in adult neurogenesis. A must read for all students entering the field.

Contents

Preface
2
A Prologue
4
Characterizing the Cell Cycle of Neurostem Cells
9
3 Detection and Phenotypic Charaterization of Adult Neurogenesis
26
A Critical Review
49
5 The Use of Reporter Mouse Lines to Study Adult Neurogenesis
81
6 Retrovirusmediated Cell Labeling
101
7 Neurospheres
119
17 Activity Dependency and Aging in the Regulation of Adult Neurogenesis
340
18 Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress Glucocorticoids Sleep and Inflammation
362
19 Regulation of Adult Neurogenesis by Neurotransmitters
397
20 Adult Neurogenesis in the Olfactory Bulb
424
21 Neurogenesis and Hippocampal Memory System
443
22 Computational Modeling of Adult Neurogenesis
463
Depression and Antidepressant Responses
483
24 Adult Neurogenesis in Neurodegenarative Diseases
503

8 Monolayer Cultures of Neural StemProgenitor Cells
135
9 Neurogenesis in the Adult Hippocampus
159
10 Adult Subventricular Zone and Ofactory Bulb Neurogenesis
175
11 Neurogenic Niches in the Adulit Mammalian Brain
207
Similarities and Differences in Stem Cell Fate Proliferation Migration and Differentiation in Distinct Forebrain Regions
226
13 Proneuronal Genes Drive Neurogenesis on the Road from Development to Adulthood
267
14 The Balance of Trophic Support and Cell Dealth in Adult Neurogenesis
283
15 Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
299
16 Genetics and Epigenetics in Adult Neurogenesis
321
25 Epilepsy and Adult Neurogenesis
534
26 Neurogenesis following Stroke Affecting the Adult Brain
549
27 Adult Neurogenesis in Teleost Fish
571
A Model for Inducible Striatal Neuronal Addition
593
A Response to Cell Loss and New Circuitry Requirements?
618
30 Adult Hippocampal Neurogenesis in Natural Populations of Mammals
643
Index
661
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