Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible TreatmentsAlicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide. |
Other editions - View all
Common terms and phrases
ABC transporters activity amastigotes amazonensis amphotericin amphotericin-B antigen antileishmanial drugs Antimicrob Agents Chemother antimony resistance BALB/C BALB/C mice Biol Chem braziliensis canine cells Clin clinical co-infected Croft cutaneous leishmaniasis cytokine disease dogs drug resistance drug target efficacy endemic enzyme epidemiological experimental expression gene genetic genome host human immune response Immunol India induced Infect Immun inhibition inhibitors intracellular isolates kala-azar kinetoplastid LdMT Leish Leishmania donovani Leishmania infantum Leishmania infection Leishmania major Leishmania parasites Leishmania species lesions lipid liposomes macrophages mechanisms metabolism mexicana Microbiol miltefosine Mol Biochem Parasitol molecular mutants overexpression P-glycoprotein parasites patients pentamidine pentavalent antimony phenotype plasma membrane Ponte-Sucre promastigotes protection protein proteomic purine recombinant reductase resistance in Leishmania role sand fly SbIII sensitivity sodium stibogluconate strains studies Sundar susceptibility therapy thiols toxicity Trans R Soc treatment tropica trypanosomatids trypanothione uptake vaccine candidates vector Viannia visceral leishmaniasis vitro vivo