Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy

Front Cover
Carlos A. Zarate Jr., Husseini K. Manji
Springer Science & Business Media, Apr 16, 2009 - Medical - 279 pages

Although our knowledge of mood disorders in general is expanding steadily, comparatively little is known about bipolar depression in particular. This book brings together leading clinicians and preclinical and clinical researchers to offer the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression.

Early chapters provide valuable diagnostic information, and review the course, outcome, and genetics of this highly heritable condition, allowing clinicians to distinguish between the various mood disorders. The book offers a thorough and unique overview of the neurobiology of the disorder, including what is known from recent neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women, and another chapter addresses the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient's symptoms and history. Finally, the book covers acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments.


This book has assembled a widely respected group of preclinical and clinical researchers who bring their expertise to bear upon this illness. It offers researchers, clinicians, and postgraduate students key insights into this devastating disorder.

 

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Contents

The history of bipolar disorders
3
The clinical diagnosis of bipolar depression
17
Course and outcome of bipolar disorder focusing on depressive aspects
29
Suicide and bipolar disorder
47
Bipolar depression Neurobiology
57
The genetic basis of bipolar disorder
59
Understanding the neurobiology of bipolar depression
77
implications for novel therapeutics
95
focus on relapse prevention studies and the impact of design on generalizability
159
Nonpharmacological somatic treatments for bipolar depression
179
Potential novel treatments for bipolar depression
191
Treatment of bipolar disorder in special populations
212
Lateonset bipolar disorder
213
Treatment of childhoodonset bipolar disorder
241
Treatment of bipolar disorder during and after pregnancy
253
Conclusion
271

therapeutic implications
117
Acute and longterm treatment of bipolar disorder
146
Pharmacological treatment of acute bipolar depression
147

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