Bile Acid Biology and its Therapeutic Implications: Proceedings of the Falk Symposium 141 (XVIII Internationale Bile Acid Meeting) held in Stockholm, Sweden, June 18 - 19, 2004
G. Paumgartner, D. Keppler, U. Leuschner, A. Stiehl
Springer Science & Business Media, Mar 2, 2005 - Medical - 276 pages
This book is the proceedings of the 18th International Bile Acid Meeting, held as the Falk Symposium 141 in Stockholm, Sweden, on June 18–19, 2004. The International Bile Acid Meetings have become some of the most important meetings in the bile acid field worldwide since Herbert Falk decided to sponsor these Symposia in biannual sequence in 1970. The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids. They have always been a forum where basic scientists and clinicians interact. Many novel results of bile acid research were first presented at these meetings. The meeting in Stockholm again attracted a large number of basic and clinical scientists interested in bile acid and biliary research from all over the world.
Knowledge about the regulation of bile acid synthesis, bile acid transport and enterohepatic circulation in health and in disease has increased considerably during recent years. Accordingly, bile acid research is alive as ever. A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids. A large part of the book is devoted to these topics.
The 18th International Bile Acid Meeting was again a truly interdisciplinary symposium at the highest scientific level. Its participants enjoyed hearing the latest reports on bile acid research in the city where so many seminal studies on bile acids were performed. It is hoped that the readers of this book will share the enjoyment.
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Multifunctional roles of bile acid biosynthetic enzymes and the isolation of a new vitamin D 25 hydroxylase
Studies on biosynthetic pathways to bile acids in human liver cells
Role of CYP3A4 as a cholesterol and bile acid metabolizing enzyme
New insights into bile acid amidation
Mechanisms of bile acid inhibition of bile acid synthesis
The farnesoid X receptor controls gene expression in a ligand and promoterselective fashion
Regulation of bile acid biosynthesis by cell signalling pathways
Feedback regulation of human bile acid synthesis
Haplotype analysis of hepatobiliary ABC transporter genes in cholecystolithiasis
Molecular elucidation of intestinal cholesterol absorption
BIOLOGICAL AND PHARMACOLOGICAL EFFECTS OF BILE ACIDS
Actions of the bile acid receptor FXR
Activation of MRP2 transport by ursodeoxycholic acid and its amidates
Role of mitogenactivated protein kinases in tauroursodeoxycholic acidinduced bile secretion in cholestatic rat liver
Bile acids and CD95 activation
Tauroursodeoxycholic acid a bile acid with in vivo antiapoptotic and neuroprotective properties
On the role of oxysterols in regulation of cholesterol homeostasis by nuclear receptors
TRANSPORT OF BILE ACIDS AND LIPIDS
Bile acid transport in Spgp Bsep knockout mice
Bile salt and glutathione coefflux mediated by multidrug resistance protein MRP4 ABCC4 a basolateral transporter of the hepatocyte
Role of farnesoid X receptor in regulating bile salt transport and synthesis
Genderspecific expression of liver organic anion transporters
Molecular mechanisms of intestinal bile acid transport
Adaptive regulation of bile salt transporters in cholestasis the role of MRPs
Adaptive hepatobiliary transporter regulation by ursodeoxycholic acid
Molecular mechanism of biliary lipid secretion
BILE ACIDS AS THERAPEUTIC AGENTS
Clinical presentation and treatment of familial unconjugated hypercholanaemia
Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation transport and detoxification...
Dose effect of ursodeoxycholic acid used in the treatment of primary biliary cirrhosis and primary sclerosing cholangitis
Highdose ursodeoxycholic acid in the management of primary sclerosing cholangitis
Chemopreventive effect of ursodeoxycholic acid in primary sclerosing cholangitis?
Ursodeoxycholic acid and colorectal carcinogenesis
Intrahepatic cholestasis of pregnancy results from the Swedish observation and intervention trials