This authoritative, timely, and comprehensively referenced compendium on the bacteriophages explores current views of how viruses infect bacteria. In combination with classical phage molecular genetics, new structural, genomic, and single-molecule technologies have rendered an explosion in our knowledge of phages. Bacteriophages, the most abundant and genetically diverse type of organism in the biosphere, were discovered at the beginning of the 20th century and enjoyed decades of used as anti-bacterial agents before being eclipsed by the antibiotic era. Since 1988, phages have come back into the spotlight as major factors in pathogenesis, bacterial evolution, and ecology. This book reveals their compelling elegence of function and their almost inconceivable diversity. Much of the founding work in molecular biology and structural biology was done on bacteriophages. These are widely used in molecular biology research and in biotechnology, as probes and markers, and in the popular method of assesing gene expression.
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Acad activity amino acid analysis antitermination assembly Bacillus subtilis bacterial Bacteriol bacteriophage lambda bacteriophage P22 bacteriophage T4 Biol C-terminal capsid Chem chromosome coat protein codon Cold Spring Harbor coliphage complex connector contains cyanobacteria cyanophage cycle dimers DNA binding DNA packaging DNA replication domain double-stranded encoded endolysin endonuclease enzyme Escherichia coli f29 DNA figure function gene expression gene product genetic genome head helicase holin homologous host cell infection initiation integrase interaction lambdoid phages late genes linear lysis lysogenic lytic lytic cycle mechanism membrane Microbiol molecular molecules morphogenesis mutants Natl Nucleic Acids nucleotide operon ORFs particles phage DNA phage P2 plasmid PRD1 Proc procapsid prohead promoter prophage recombination region regulation repressor residues ribosome RNA polymerase RNAP role scaffolding protein similar specific SPP1 strains strand structure subtilis subunit synthesis T4 DNA tail fiber terminase tion viral virion Virology virus viruses vitro vivo wild-type