Airway Mucus: Basic Mechanisms and Clinical Perspectives

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D.F. Rogers, Michael Lethem
Springer Science & Business Media, Sep 23, 1997 - Medical - 388 pages
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Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.

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Airway Surface Liquid Concepts and Measurements
Structure and Biochemistry of Human Respiratory Mucins
Airway Mucin Genes and Gene Products
The Microanatomy of Airway Mucus Secretion
Mechanisms Controlling Airway Ciliary Activity
Rheological Properties and Hydration of Airway Mucus
Goblet Cells Physiology and Pharmacology
Airway Submucosal Glands Physiology and Pharmacology
Experimental Induction of Goblet Cell Hyperplasia In Vivo
Mucus Hypersecretion and Its Role in the Airway Obstruction of Asthma and Chronic Obstructive Pulmonary Disease
Mucus and Airway Epithelium Alterations in Cystic Fibrosis
DrugMucus Interactions
Therapeutic Approaches to the Lung Problems in Cystic Fibrosis
Therapeutic Approaches to Airway Mucous Hypersecretion

MucusBacteria Interactions

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Page 358 - Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis.
Page 362 - Engelhardt, JF, Yankaskas, JR, Ernst, SA, Yang, Y., Marino, CR, Boucher, RC, Cohn, JA, and Wilson, JM ( 1992).

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