Current Medicinal Chemistry |
Common terms and phrases
affinity aggregation amino acid amyloid amyloid fibrils amyloidosis analogues antiarrhythmic agents antibiotic antihistamines Ap peptides APD-prolongation arrhythmias reported assay astemizole Bentham Science Publishers benzodiazepine binding biological activity carbon carboxylic cardiac effects cardiotoxicity cell cell-surface cetirizine Class III antiarrhythmic cleavage CO2H combinatorial chemistry Congo Red Current Medicinal Chemistry derivatives drugs enzyme fexofenadine fibril formation function glycoconjugates glycoproteins glycosides guinea pig H OH haemagglutinin hydrolysis hydrophilic hydroxyl group hydroxyzine IDOX increase influenza A sialidase influenza virus haemagglutinin influenza virus sialidase inhibition of influenza inhibitors inhibitory potency interactions ligands linkage linker metabolism modification modified sialic acids molecules Neu5Ac Neu5Ac2en Neu5Aco.2Me NHAc nicotine peptide Piperidine plasma potential prepared QT intervals QT-prolongation receptor resin resin-bound result rifampicin Scheme screening sialic acid residue sialic acid-recognising proteins sialic acids sialidase sialoglycoconjugates sialosides sialyl side-chain solid-phase synthesis structures substituent substrate specificity sugar sulfonate TentaGel terfenadine torsades de pointes vitro