Signalling Pathways in Apoptosis
Apoptosis, or programmed cell death, is a necessary process by which a cell may die without adversely affecting its environment. It plays a crucial role in normal development, and in the body's defence mechanisms against disease. Too much cell death is destructive, leading to neurodegenerative diseases and impaired development. Conversely, too little cell death can lead to an increased susceptibility to cancer and sustained viral infection. Apoptosis is a matter of balance
Dramatic progress has been made in the study of apoptosis over the past decade. One of the most rapidly expanding knowledge bases being established is on the molecular mechanisms controlled by a variety of gene products including Bcl-2, caspases, death receptors, and proteolytic targets, as well as the central role of the mitochondrion. The major challenge in apoptosis research is how the protein products involved operate in an intricate web of signaling pathways that also play a crucial role in cell proliferation and differentiation. This book concentrates on elucidating these signal transduction mechanisms, an area not properly reviewed by other apoptosis texts.
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Acad acid Alnemri apoptosis induced apoptotic baculovirus Bcl-xL binding Biochem Biol Caenorhabditis elegans cascade caspase activation caspase-3 caspases cell cycle cell lines cell survival cell types cellular ceramide Chem Chinnaiyan cleavage cleaved cloning CrmA cysteine protease cytochrome cytokines cytoplasmic cytotoxic death domain death receptors Dixit DNA fragmentation downstream Drosophila effector elegans EMBO encodes expression FADD Fernandes-Alnemri fibroblasts function gene granzyme growth factor Hannun homolog Horvitz human Immunol induce apoptosis induction of apoptosis inhibition inhibitors interaction interleukin involved isoenzymes Kroemer lamin ligand lymphocytes MAPK Marchetti mechanism mediated membrane mice mitochondrial molecular molecules mutations Natl neuronal novel nuclear Oncogene overexpression PARP perforin phosphorylation PI3K PKC isoenzymes Proc programmed cell death protein kinase proteolytic radiation regulation response role Science signal transduction signalling pathways specific sphingolipids sphingomyelin substrates subunits Susin transcription translocation trigger tumor necrosis factor virus vitro vivo Wang Zamzami