The Alzheimer's Project: Momentum in Science
Alzheimer's disease is the second most-feared illness in America, following cancer. It affects as many as 5 million Americans, a number that could soar to 16 million by 2050. It is estimated that, unless effective preventions are discovered, 10 million baby boomers will eventually develop this irreversible and devastating brain disorder. Until recently, medical news on Alzheimer's disease was not comforting. But in the past few years, advances in many scientific areas - from diagnostic imaging to genetic analysis - have led to an explosion of knowledge with implications for treatment and prevention. This is an exciting time of discovery in Alzheimer's research. Through The Alzheimer's Project film series, HBO Documentary Films illuminates the vital breakthroughs occurring in the field. One of the central films in this series, Momentum in Science, brings us inside the laboratories and clinics of the nation's top scientists and physicians who are clearing the path to a deeper understanding of Alzheimer's disease. By capturing the exhilaration of these scientists and casting light on their groundbreaking discoveries, the film seeks to bring a wider understanding of the disease and new hope for future treatment. This book offers a closer look at the advances of this scientific frontier. It investigates the complex cascade of events that occurs inside the brain when someone has Alzheimer's disease and shows how scientists are working to interrupt this process and ultimately prevent the disease. In accessible prose, it examines specific evidence of momentous progress, from the triumphant discovery of the unique role of the beta-amyloid and tau proteins, to the use of PET scans to track changes in the brain and the analyses of cerebrospinal fluid to identify biomarkers that will help us predict who will develop the disease in the future. It also looks at current drug development and at what we can do as individuals to potentially reduce our risk of developing the disease.
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ability activity Alzheimer’s Association Alzheimer’s disease research Alzheimer’s Project amyloid plaques areas autopsy axon Bennett beta beta-amyloid peptide beta-amyloid plaques body brain tissue cause changes cholesterol clinical trials cognitive decline cognitive reserve compound Cotman damage DeCarli dementia developing Alzheimer’s disease diabetes diagnosed diet discovery disease process Disease Research Center drug development early-onset effects Elan Pharmaceuticals exercise factors fMRI genetic glucose Health hippocampal formation human identify Image inflammation inflammatory Institute on Aging insulin resistance Klunk levels lifestyle Mathis Memory and Aging memory loss memory problems metabolic mice microglia molecules mutations National Institute nerve cells neurofibrillary tangles neurons normal oligomers participants pathology pathways person PET scans Petersen plaques and tangles potential prevent progress research volunteers role scientists Selkoe Sperling stage studies suggest susceptibility genes symptoms target tau protein tau tangles tests tion treatment Trojanowski understand vascular disease