Scleroderma: From Pathogenesis to Comprehensive Management

Front Cover
John Varga, Christopher P. Denton, Fredrick M. Wigley, Yannick Allanore, Masataka Kuwana
Springer, Nov 7, 2016 - Medical - 743 pages

Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.


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Epidemiology Genetics and Classification
The Biological Basis of Systemic Sclerosis
Cardiovascular Manifestations and Management
Pulmonary Manifestations and Management
Gastrointestinal Manifestations and Management
Skin Musculoskeletal and Other Complications
Management and Outcome Assessment
Case Studies Approach to Complex Clinical Problems

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About the author (2016)

John Varga, MD

John and Nancy Hughes Distinguished Professor

Feinberg School of Medicine

Director, Northwestern Scleroderma Program

Chicago, Illinois, USA

Christopher P. Denton, PhD, FRCP

Professor of Experimental Rheumatology

Centre for Rheumatology and Connective Tissue Diseases

Division of Medicine

University College London

London, United Kingdom

Fredrick M. Wigley, MD

Martha McCrory Professor of Medicine

Department of Medicine/Rheumatology

The Johns Hopkins University School of Medicine

Baltimore, Maryland, USA

Yannick Allanore, MD

Service de Rhumatologie A

UniversitÚ Paris Descartes,

H˘pital Cochin

Paris, France

Masataka Kuwana, MD, PhD


Department of Allergy and Rheumatology

Nippon Medical School Graduate School of Medicine

Tokyo, Japan

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