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acute myocardial infarction adrenal aldosterone angina pectoris anticoagulant anticoagulant therapy arrhythmias arterial thrombosis aspirin atherosclerosis blood flow blood pressure cardiovascular cause cholesterol circulation Clin clinical trials clofibrate clotting coagulation concentration coronary artery disease coronary heart disease Cushing's syndrome decreased diabetes mellitus diagnosis diet dipyridamole dose effect elevated embolism endothelial Engl enzyme essential hypertension estrogens fibrillation glucose Groningen hormone hyper hyperlipoproteinemia hypertriglyceridemia hypothyroidism increased induced insulin Lancet lesions lipoprotein lipase low renin lower measurements mechanism metabolism mortality Netherlands normal occlusion occurs oral anticoagulants oral contraceptives oxygen patients peripheral placebo plasma plasma cholesterol platelet platelet aggregation platelet function platelet inhibiting drugs platelet survival prevention primary reduced renal renin risk factors serum cholesterol smooth muscle cell studies sudden cardiac death sudden death sulphinpyrazone surgical thrombi thromboembolism thrombosis thyroid tion tissue tolbutamide treated triglyceride type II hyperlipoproteinemia vascular disease venous ventricular vessel xanthomas