Immune RegulationMarc Feldmann, N. A. Mitchison Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs. |
Contents
Molecular and Functional Analysis of the Human T Cell | 3 |
Oreste Acuto Marina Fabbi and Ellis L Reinherz | 15 |
Non AntigenSpecific Surface Molecules Involved in | 27 |
Copyright | |
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Acad amino acid anti antigen presentation antigen-specific assay autoimmune BCDF BCGF beta chain binding biochemical Cancer cDNA cell activation cell clones cell function cell lines cell populations cell receptor cell surface cell types chloroquine clonal clones CTL clones culture cytolytic cytotoxic dendritic cells differentiation effect effector encoded epithelial cells Feldmann gene germinal center growth factors HCGF helper cells HLA-D/DR homology HTLV HTLV-I human hybridoma IgE-BF IL-2 receptor immune response Immunol Immunology induced infection inhibition interaction isolated levels liposomes lymphocytes lymphoid lymphokines lymphomas MAbs macrophages membrane MHC antigens MHC molecules mice mitogen molecular monoclonal antibodies monocytes mouse mRNA murine Natl normal peptide phenotype presenting cells Proc processing production proliferation protein purified recognition restricted role secretion sequence specific spleen stimulation structure studies subunit suggested supernatant suppressor cells suppressor factor T-cell target cells thymic thymocytes thymus transfected virus viruses vitro vivo