Prions: Novel Infectious Pathogens Causing Scrapie and Creutzfeldt-Jakob DiseaseStanley B. Prusiner, Michael P. McKinley |
Contents
An Introduction to Scrapie and CreutzfeldtJakob | 1 |
The Prion Hypothesis | 17 |
IV | 24 |
Copyright | |
127 other sections not shown
Common terms and phrases
activity aggregates Alper amyloid plaques animals antibodies appear bacteriophage Barry Bendheim biological Bolton caused cells changes clinical compared Congo red contain Creutzfeldt-Jakob Disease curve DeArmond described detected determined developed digestion dilution dose effects evidence experimental experiments extracts Figure fractions Gajdusek gene Gibbs goats gradient Groth Hadlow hamster brain host human inactivation increased incubation period indicate infectivity inoculation irradiation isolate kuru lanes less macromolecules McKinley measured method mice molecular molecules months mouse Nature neuronal normal nucleic acid observed occur particles patients possible preparations present prion proteins prion rods procedure progressive properties purified radiation References regions reported Reproduced resistant S. B. Prusiner samples scrapie agent scrapie prion scrapie-infected sequence sheep shown signs similar Slow specific stain structure studies sucrose suggested Table tissue titer transmission units viroids virus viruses York