Modern Methods of Organic Synthesis
The fourth edition of this well-known textbook discusses the key methods used in organic synthesis, showing the value and scope of these methods and how they are used in the synthesis of complex molecules. All the text from the third edition has been revised, to produce a modern account of traditional methods and an up-to-date description of recent advancements in synthetic chemistry since the previous edition. A new chapter on the functionalisation of alkenes has been included and greater emphasis on highly stereoselective reactions and radical chemistry has been placed. Reference style has been improved to include footnotes on each page, allowing easy and rapid access to the primary literature. The book will be of significant interest to chemistry and biochemistry students at advanced undergraduate and graduate level, as well as researchers in academia and industry who wish to familiarise themselves with modern synthetic methods.
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a.p-unsaturated acetate adduct aldehyde aldehyde or ketone aldol reaction alkene alkenyl alkynes allylic alcohol amine anion aromatic asymmetric B. M. Trost benzylic borane boron carbon atom carbonyl carbonyl compounds carbonyl group carboxylic acid catalyst Chem chemistry chloride CO2Et CO2Me complex converted cyclic cycloaddition cycloaddition reactions cyclopropane derivatives diastereomer Diels-Alder reaction diene dienophile dihydroxylation diol double bond electron electrophiles elimination enantioselectivity enol ether epoxidation ester example Fleming formation formed functional groups gave give Grignard reagent high yield hydroboration hydrogen atom intermediate intramolecular isomer ketone lactone less-hindered Lewis acid lithium aluminium hydride metal method methyl mixture normally nucleophilic obtained occurs Organic Synthesis organolithium species Oxford oxidation oxygen palladium Pergamon Press prepared presence proton radical react reactive readily rearrangement reduction regioselectivity ring salt Scheme selectivity silyl sodium solvent stereoselectivity substituents substrate sulfone takes place temperature Tetrahedron trans transition unsaturated ylide Z-alkene