Goodman and Gilman's the Pharmacological Basis of Therapeutics**** A classic text, now in its 50th year, recommended as a first purchase by Brandon-Hill. The new edition reflects the impact of modern biology since the previous edition in 1985: novel drugs produced by recombinant DNA technology, detailed knowledge of the structure and function of dozens of receptors, major progress in rational drug design, and improved treatment from appreciation of the importance of interplay between pharmacodynamics and pharmacokinetics. Annotation copyrighted by Book News, Inc., Portland, OR |
Contents
SECTION | 1 |
MECHANISMS OF DRUG ACTION AND THE Relation | 33 |
PRINCIPLES OF TOXICOLOGY Curtis D Klaassen | 49 |
Copyright | |
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absorption acid activity acute administration adrenergic adrenergic receptors agonists alcohol amines analgesia analgesic anesthesia anesthetic antagonists antidepressants antipsychotic atropine autonomic B-adrenergic barbiturates benzodiazepines binding blockade blood flow blood pressure brain Ca2+ cardiac cardiovascular catecholamines cause cells central Chapter chemical cholinergic chronic Clin clinical clonidine compounds concentration decrease depression diazepam disease dopamine dosage doses drug efficacy enflurane enzyme epinephrine ethanol excreted fects fibers function GABA ganglia ganglionic gastrointestinal half-life halothane hepatic hypotension increase inhalation inhibition inhibitors injection interactions intravenous isoflurane levodopa local anesthetics mechanisms membrane metabolism metabolites morphine muscarinic naloxone nerve nervous system neuroleptic neuromuscular neurons nicotinic norepinephrine occur opioids oral oxygen patients pentazocine peptides peripheral pharmacokinetic Pharmacol pharmacological phenobarbital phenytoin plasma potential produce proteins pulmonary receptors release renal respiratory response result seizures side effects smooth muscle spinal stimulation sympathetic Symposium symptoms syndrome therapeutic therapy tion tissues tive tolerance toxicity transmitter treatment tricyclic usually vascular