Kindling 4

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Juhn A. Wada
Springer Science & Business Media, Mar 8, 2013 - Science - 490 pages
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This is the proceedings of the fourth in a series of inter national gatherings on kindling held on the University of British Columbia campus, June 15-17, 1989. Since the last gath ering in 1985, kindling continues to attract an ever-increasing number of investigators as reflected by the phenomenal increase in the number of kindling-related research reports. No other acute or chronic model has been exploited so extensively using electrophysiological, pharmacological, biochemical and behav ioural approaches involving a variety of brain sites and ani mal species. The continuing search, during the past few years, for the mechanism underlying the enduring change induced by kindling is beginning to shed some light on aspects of its molecular basis and to suggest the future direction of research. The late Graham Goddard, the original kindler, would have been delighted with this development. We were all shocked and saddened by his tragic death, but his spirit is very much alive among all of us who gathered together to share new information and collectively reassess the present state of knowledge at this symposium. I must say that we miss him very, very much. We know he is happy in his heaven knowing that he accomplished more in a short lifetime than most and that his love for mankind, and life's challenges, remain as a legacy, and goal, for us all.
 

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Contents

Spontaneous Electrographic Seizures in the Hippocampal
11
Is the Pyriform Cortex Important for Limbic Kindling?
21
A Sequential DoubleLabel
32
Seizure Mechanisms in the Piriform Cortex
45
Doublelabel Quantitative Autoradiographic Studies
61
Alterations of Synaptic Ultrastructure Induced
74
Forebrain and Brainstem Mechanisms Governing Kindled
93
An Experimental
113
Kindling and Excitatory Amino Acids 241
240
Effect of Selective Lesions Within the Substantia Nigra
253
Pharmacological and Toxicological Evaluation
267
Contingent Tolerance to the Anticonvulsant Effects
282
Can KindlingInduced Sleep Pathology be Corrected
299
Basic Mechanisms Underlying SeizureProne and Seizure
312
Human
329
Pharmacological Dissociation Between the Mechanisms
342

The GABA Hypothesis of Kindling
127
Noradrenaline and Kindling Revisited
141
Mechanisms of Kindling in Developing Animals
157
The Kindling Process and Vulnerability to Status
169
Frequency and TimeDomain EEG Topographic Analysis
184
NMethylDAspartate NMDA Receptors and the Kindling
197
Does Electrical and Excitatory Amino Acid Kindling Share
209
Involvement of Excitatory Amino Acids in the Mechanisms
227
Differential
357
Erosion of Kindled Epileptogenesis and KindlingInduced
382
Claus trum and Amygdaloid Kindling
397
Midline Thalamus and Amygdaloid Kindling 4 09
409
Adenosine Involvement in Kindled Seizures
423
Dr Calvos Presentation and Discussion
441
Index l 73
462
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