Physiologic and Chemical Basis for Metal Toxicity

Front Cover
Springer Science & Business Media, Mar 14, 2013 - Medical - 238 pages
0 Reviews
Our purpose is to provide understanding for appropriate use of metals in a technical society. Knowledge of metal toxicity is needed for the preven tion, prediction, diagnosis, and therapy of adverse reactions from excess metals in mammals. Metal Toxicity in Mammals is presented in two volumes. Volume 1, Physiologic and Chemical Basis for Metal Toxic ity, provides the basis for understanding the toxic actions of metals recorded in Volume 2, Chemical Toxicity of Metals and Metalloids. The details and bases for many concepts summarized in Volume I are given, with appropriate references, in Volume 2. Thus, references for specific items in Volume 2 are not generally given in Volume 1. The authors reviewed the known toxicity of several heavy metals in anticipation of their use as multinutrient markers for NASA. As more and more metals were considered, the need for a complete review became obvious. This treatise supplants onerous searches of metal-toxicity litera ture up to 1975 and reviews the toxicity of all the metals of the periodic table on the basis of available relevant data. Books on pharmacological, nutritional, medical, veterinary, or industrial toxicity contain information about selected metals. More complete data about metals of public concern, such as mercury, lead, and cadmium, may be found in numerous books and reviews. The reader should refer to general texts and basic reference works, when specific references are not given, for general information.
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Chapter
1
Stimulatory Metals
9
Safety
20
Analytic Procedures
26
MODES OF INTAKE AND ABSORPTION
39
Inhalation
59
Dermal Absorption and Administration
80
Other Parenteral Routes
86
Physicochemical Properties of Biologic Significance
105
Hard and Soft Acids and Bases Theory
111
ProteinMetal Interactions
120
Biologic MembraneMetal Interactions
126
Teratogenicity
153
SUMMARY AND OVERVIEW OF METAL TOXICITY
161
Periodicity and Toxicity
188
APPENDIX B
197

Chapter 3
93
Homeostasis
99

Common terms and phrases

Bibliographic information