Professional Communications, 2002 - Medical - 352 pages
Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice are reviewed.
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Abbreviations abciximab acute coronary syndromes acute myocardial infarction alteplase angioplasty Ann Intern antibodies anticoagulant therapy antiplatelet therapy antithrombotic therapy aPTT artery disease aspirin atrial fibrillation benefit binding bleeding blood bolus Circulation clinical trials clopidogrel clotting coagulation coronary artery death dose drug effect embolism Engl enoxaparin eptifibatide fibrinogen fibrinolytic fibrinolytic therapy Figure glycoprotein IIb/IIIa GPIIb/IIIa GPIIb/IIIa receptor antagonists heart valve hemorrhage heparin high-risk hirudin increased infusion inhibitor intravenous ischemia ischemic Lancet LMWH low molecular weight mg bid molecular weight heparin monitoring mutation nonfatal occlusion oral anticoagulant outcomes patency percutaneous coronary intervention placebo plasma platelet platelet activation platelet aggregation platelet function platelet inhibition protein prothrombin randomised randomized trial recurrent reduced reteplase revascularization risk factors stent streptokinase stroke Study surgery TABLE Thromb Haemost thrombin Thrombolysis thrombophilia thrombotic thrombus ticlopidine tients tion Tirofiban treatment unfractionated heparin unstable angina vascular disease venous thromboembolism venous thrombosis warfarin