Origination of Organismal Form: Beyond the Gene in Developmental and Evolutionary Biology

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MIT Press, 2003 - Science - 332 pages
A more comprehensive version of evolutionary theory that focuses as much on the origin of biological form as on its diversification.

The field of evolutionary biology arose from the desire to understand the origin and diversity of biological forms. In recent years, however, evolutionary genetics, with its focus on the modification and inheritance of presumed genetic programs, has all but overwhelmed other aspects of evolutionary biology. This has led to the neglect of the study of the generative origins of biological form.

Drawing on work from developmental biology, paleontology, developmental and population genetics, cancer research, physics, and theoretical biology, this book explores the multiple factors responsible for the origination of biological form. It examines the essential problems of morphological evolution--why, for example, the basic body plans of nearly all metazoans arose within a relatively short time span, why similar morphological design motifs appear in phylogenetically independent lineages, and how new structural elements are added to the body plan of a given phylogenetic lineage. It also examines discordances between genetic and phenotypic change, the physical determinants of morphogenesis, and the role of epigenetic processes in evolution. The book discusses these and other topics within the framework of evolutionary developmental biology, a new research agenda that concerns the interaction of development and evolution in the generation of biological form. By placing epigenetic processes, rather than gene sequence and gene expression changes, at the center of morphological origination, this book points the way to a more comprehensive theory of evolution.

 

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Contents

The Forgotten Cause
3
Convergence and Homoplasy in the Evolution of Organismal Form
33
The Evolution of Morphological Organization
51
RELATIONSHIPS BETWEEN GENES AND FORM
71
The Reactive Genome
87
Structural Cues Allow Diverse
103
Genes Cell Behavior and the Evolution of Form
119
PHYSICAL DETERMINANTS OF MORPHOGENESIS
133
A Biochemical Oscillator Linked to Vertebrate Segmentation
183
Organization through IntraInter Dynamics
195
The Evolution of Morphogenetic
221
ORIGINATION AND EVOLVABILITY
241
Genetic and Epigenetic Factors in the Origin of the Tetrapod Limb
265
Boundary Constraints for the Emergence of Form
305
Contributors
323
Copyright

Gradients Diffusion and Genes in Pattern Formation
165

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About the author (2003)

Gerd B. M ller, is Professor of Zoology and Head of the Department of Theoretical Biology at the University of Vienna and President of the Konrad Lorenz Institute for Evolution and Cognition Research.

Stuart Newman is Professor of Cell Biology and Anatomy at New York Medical College.

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