Microarray Innovations: Technology and Experimentation

Front Cover
Gary Hardiman
CRC Press, Apr 2, 2009 - Medical - 314 pages
In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr
 

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Contents

Chapter 1 Introduction to Gene Expression Profiling with DNA Microarray Technology
1
Chapter 2 Introduction to LargeScale Gene Expression Data Analysis
11
Chapter 3 The Statistical Design and Analysis of Gene Expression Data
25
Chapter 4 Laboratory Automation for Microarray Experimentation
33
Chapter 5 How to Evaluate a Microarray Scanner
41
Chapter 6 The Role of Substrates in Microarray Experimentation and How to Choose the Correct Coating for Microarraying
53
Chapter 7 Toward Highly Efficient Automated Hybridizations
71
Chapter 8 Characterization of Microarray Hybridization Stoichiometry
87
Chapter 12 A Systematic Comparison of Gene Expression Measurements across Different Hybridization Based Technologies
145
Methods and Analysis
175
Progress toward DNA Diagnostics
207
Chapter 15 New Applications for Microarrays
225
Chapter 16 Development of an Oligonucleotide Microarray for Mutational Analysis Using Single or Multiple Sample Hybridization
243
Chapter 17 Development of an Integrated Molecular Diagnostics Test to Identify Respiratory Viruses
259
Chapter 18 Microarrays in Neuroscience
271
Chapter 19 Optimization of Protein Array Fabrication for Establishing HighThroughput UltraSensitive Microarray Assays for Cancer Research
289

Chapter 9 Data Normalization Selection
97
Chapter 10 Methods for Assessing Microarray Performance
119
Chapter 11 Comparison of Different Normalization Methods for Applied Biosystems Expression Array System
127
Index
301
Back cover
339
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