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abrasion achieved anesthesia anesthetic antibiotic antibiotic solution antivenin applied arterial avulsion bacterial blood supply bone bridement burn injury burn wound chronic wounds clean closed collagen cover coverage damage diabetic distal donor dressing techniques early edema epithelial cells epithelial migration eschar escharotomy excision exposed facial factitious wound fibroblasts Figure continues foot foreign material free flap frontalis muscle full-thickness skin gauze granulating surface granulation tissue hand healing process healthy granulation human bite infection inhibit injury irrigated ischemia laceration layer long finger lower extremity Lynch DJ malignancy ment meshed skin muscle necrotic tissue non-vital tissues normal nutritional ointment operating room packing partial-thickness patient pressure produce removed require result skin graft soft tissue soleus muscle split-thickness skin graft subcutaneous tissue surface wound surgery surgical debridement suture material tendon therapy tients tion tissue loss trauma treatment ulcer vascular venom wound area wound closure wound control wound edges wound environment wound healing wound management wound surface