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acid activity altered hepatic foci alveolar analysis animals antibodies autometallographic BANNAscH biochemical carcinogenesis carcinogens cells cellular chemicals concentration copper cultured Cytochem Cytochemistry cytochrome P-450 cytoplasm DANscHER demonstration detection differentiation distribution dose Drukker Eds effects electron microscopic elements Environmental Toxicology enzymes epithelial exposed exposure Fischer Verlag gene glycogen gold Graumann Ha-ras hepatic hepatocarcinogenesis hepatocytes histochemistry immunohistochemical increase induced ions kidney LAMMA laser lectin lesions levels light microscopic liver tumors localization lung lysosomes macrophages membrane mercuric chloride mercury metabolism metals mice microanalysis microprobe molecular MøLLER-MADSEN morphological mouse mutations neoplastic Nephrotoxicity neurons normal observed oncogenes organic oxide Pathol peroxisome proliferation peroxisomes phenobarbital pneumocytes preneoplastic probe Progress in Histo protein proximal tubule Purkinje cells quantitative rat liver reaction renal samples selenium silver enhancement sodium selenite specific staining studies technique tion Tool in Environmental toxic Toxicol tubule ug/g DW ultrastructural vitro x-ray xenobiotics zinc