Immunology and Evolution of Infectious Disease

Front Cover
Princeton University Press, Jul 21, 2002 - Medical - 348 pages

From HIV to influenza, the battle between infectious agents and the immune system is at the heart of disease. Knowledge of how and why parasites vary to escape recognition by the immune system is central to vaccine design, the control of epidemics, and our fundamental understanding of parasite ecology and evolution. As the first comprehensive synthesis of parasite variation at the molecular, population, and evolutionary levels, this book is essential reading for students and researchers throughout biology and biomedicine.

The author uses an evolutionary perspective to meld the terms and findings of molecular biology, immunology, pathogen biology, and population dynamics. This multidisciplinary approach offers newcomers a readable introduction while giving specialists an invaluable guide to allied subjects. Every aspect of the immune response is presented in the functional context of parasite recognition and defense--an emphasis that gives structure to a tremendous amount of data and brings into sharp focus the great complexity of immunology. The problems that end each chapter set the challenge for future research, and the text includes extensive discussion of HIV, influenza, foot-and-mouth disease, and many other pathogens.

This is the only book that treats in an integrated way all factors affecting variation in infectious disease. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For molecular biologists, immunologists, and evolutionary biologists, this book provides new insight into infectious agents, immunity, and the evolution of infectious disease.

 

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Contents

II
3
III
11
IV
13
V
14
VI
15
VII
16
VIII
19
IX
20
LV
135
LVI
136
LVII
144
LVIII
148
LIX
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LX
151
LXI
153
LXII
164

X
22
XI
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XII
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XIII
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XV
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XVI
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XVII
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XVIII
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XIX
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XX
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XXI
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XXII
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XXIII
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XXIV
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XXV
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XXVI
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XXVII
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XXVIII
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XXIX
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XXX
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XXXI
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XXXII
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XXXIII
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XXXIV
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XXXV
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XXXVI
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XXXVII
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XXXVIII
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XXXIX
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XL
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XLI
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XLII
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XLIII
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XLIV
102
XLV
106
XLVI
109
XLVII
111
XLVIII
112
XLIX
115
L
121
LI
124
LII
125
LIII
129
LIV
132
LXIII
166
LXIV
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LXV
173
LXVI
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LXVII
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LXVIII
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LXIX
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LXX
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LXXII
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LXXIV
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LXXV
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LXXVI
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LXXVII
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LXXVIII
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LXXIX
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LXXX
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LXXXI
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LXXXII
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LXXXIII
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LXXXIV
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LXXXV
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LXXXVI
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LXXXVII
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LXXXVIII
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LXXXIX
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XC
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XCI
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XCII
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XCIII
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XCIV
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XCV
246
XCVI
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XCVII
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XCVIII
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XCIX
255
C
260
CI
265
CIII
266
CV
267
CVI
268
CVII
269
CVIII
313
CIX
337
Copyright

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Common terms and phrases

Popular passages

Page 272 - Benjamin DC, Berzofsky JA, East IJ, Gurd, FRN, Hannum C., Leach SJ, Margoliash E., Michael JG, Miller A., Prager EM, Reichlin M., Sercarz EE, Smith-Gill SJ, Todd PE, and Wilson AC 1984. The antigenic structure of proteins: A reappraisal. Annu. Rev. Immunol. 2: 67-101.
Page 276 - Coffin JM (1995) HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.
Page 270 - Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, YJ, Pulendran, B.

About the author (2002)

Steven A. Frank is Professor of Evolutionary Biology at the University of California, Irvine, and the author of Foundations of Social Evolution (Princeton).

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