Oxidative StressHelmut Sies |
Contents
Strand Breakage in DNA and Polynucleotides in | 26 |
Base Damage in | 33 |
Organic Peroxy Free Radicals as Ultimate Agents | 41 |
Copyright | |
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Acta activity addition agents altered antioxidant appears Biochem Biol biological Biophys break Ca2+ Ca2+ release cause cells cellular changes Chem chemical compounds concentration containing cytochrome damage decrease dehydrogenase dependence disulfide drugs effect electron enzyme et al evidence fatty acids formation formed free radicals function glucose glucose-6-phosphate glutathione GSSG H₂O₂ hepatocytes hydroperoxide important inactivation increased indicates induced inhibition initiation injury involved ions isolated known levels lipid peroxidation liver London measured mechanism membrane menadione method microsomes mitochondria mixed disulfides NADPH Nature O₂ observed occur organic oxidase oxidative stress oxygen peroxidase peroxyl radicals Pharmacol potential presence production promotion protection protein pyridine nucleotides quinones Radiat radicals reaction recently red cells reductase reduction release response role showed shown Sies solution species stimulated studies superoxide t-butyl Table thiol tion tissue toxicity vitamin vivo Willson York