Toward Replacement Parts for the Brain: Implantable Biomimetic Electronics as Neural Prostheses

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Theodore W. Berger, Dennis Glanzman
MIT Press, 2005 - Medical - 405 pages

The latest advances in research on intracranial implantation of hardware models of neural circuitry.

The continuing development of implantable neural prostheses signals a new era in bioengineering and neuroscience research. This collection of essays outlines current advances in research on the intracranial implantation of devices that can communicate with the brain in order to restore sensory, motor, or cognitive functions. The contributors explore the creation of biologically realistic mathematical models of brain function, the production of microchips that incorporate those models, and the integration of microchip and brain function through neuron-silicon interfaces. Recent developments in understanding the computational and cognitive properties of the brain and rapid advances in biomedical and computer engineering both contribute to this cutting-edge research.

The book first examines the development of sensory system prostheses--cochlear, retinal, and visual implants--as the best foundation for considering the extension of neural prostheses to the central brain region. The book then turns to the complexity of neural representations, offering, among other approaches to the topic, one of the few existing theoretical frameworks for modeling the hierarchical organization of neural systems. Next, it examines the challenges of designing and controlling the interface between neurons and silicon, considering the necessity for bidirectional communication and for multiyear duration of the implant. Finally, the book looks at hardware implementations and explores possible ways to achieve the complexity of neural function in hardware, including the use of VLSI and photonic technologies.



Microelectronic Array for Stimulation of Large Retinal Tissue Areas
Imaging TwoDimensional Neural Activity Patterns in the Cat Visual
Examples from the Auditory System
A Protocol for Reading the Mind
A Code for
Mathematical Modeling as a Basic Tool for Neuromimetic Circuits
RealTime Spatiotemporal Databases to Support Human Motor Skills
LongTerm Functional Contact between Nerve Cell Networks
Achievements and Foreseeable Challenges
BrainImplantable Biomimetic Electronics as a Neural Prosthesis
HighPrecision Computation from Low
Hybrid ElectronicPhotonic Multichip Modules for Vision and Neural
Reconfigurable Processors for Neural Prostheses
The Merging of Computational Neural

Building Minimalistic Hybrid Neuroelectric Devices

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About the author (2005)

Theodore W. Berger is Professor of Biomedical Engineering in the School of Engineering at the University of Southern California. Dennis L. Glanzman is Program Chief for Theoretical and Computational Neuroscience at the National Institute of Mental Health (NIMH).

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