Oxidative Stress: Oxidants and AntioxidantsHelmut Sies Life on earth utilizes oxygen and oxygen metabolites in energy conversion, and the constant generation of prooxidants is an essential attribute to aerobic life. This challenge is met by a system of antioxidants in order to maintain a steady state; a disturbance in the prooxidant/antioxidant system is defined as oxidative stress.**In recent years oxidants and antioxidants have attracted widespread interest in many scientific disciplines ranging from free radical chemistry to biochemistry, biology, pharmacology, toxicology, and medicine. This book highlights some of the fascinating research developments in the field, including occurrence of oxidants, defense against oxidants, processes and cell responses, and clinical aspects of oxidative stress. Occurrence of oxidants**Defense against oxidants**Processes and cell response**The role of research in the area of clinical medicine |
Contents
Oxygen radicals and air pollution | 21 |
UVA 320380 nm radiation as an oxidative stress | 57 |
Nonradical mechanisms for the oxidation | 85 |
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Acad acid action activity addition agents aldehydes antioxidants appears ascorbic binding Biochem Biol biological Biophys Cancer Carcinogenesis carcinogenic catalase caused cells cellular Chem chemical coli Commun compounds concentrations containing cultured damage demonstrated dependent effects endonuclease endothelium-derived relaxing factor enhanced enzyme Esterbauer et al evidence Figure formation free radicals function glutathione groups H₂O₂ human hydrogen peroxide hydroperoxides important increased indicates induced inhibition initiation interaction intermediates involved leads levels lipid peroxidation liver lung macrophages mechanism membrane metabolism metabolites Mutat Nature observed occurs organic oxidative stress oxygen peroxidase Pharmacol plasma platelets possible presence Press Proc protection protein quinone radiation reaction reactive recently reduced release repair reported response role showed shown specific stimulation studies substrate suggested superoxide synthesis Table tissues toxicity tumour types vitro vivo