Abl Family Kinases in Development and Disease

Front Cover
Anthony Koleske
Springer Science & Business Media, May 8, 2008 - Medical - 125 pages

Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.

 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Selected pages

Contents

Mechanisms of Activation of Abl Family Kinases
1
Activation of Abl by SH3 Domain Ligands
3
Activation of Abl by Phosphorylation
4
Activation by Oligomerization
6
Role of Abl Family Kinases in Growth FactorMediated Signaling
11
Regulation of Cell Adhesion Responses by Abl Family Kinases
16
The BcrAbl Fusion Protein Causes Defects in Integrin Function
17
Abl Family Kinases Mediate Cellular Responses to Integrin Engagement
18
Regulation of Cell Motility by Abl Family Kinases
68
Domain Structure and Developmental Function of Abl Family Kinases
69
Negative Regulation of Cell Migration by Abl Kinases through Uncoupling of CASCrk Complexes
70
Abl Regulation of HGFInduced Cell Migration
72
Abl Regulation of PDGFBBInduced Cell Migration
73
Oncogenic Forms of ABL Family Kinases
77
vABL
79
BCRABL
82

Abl Family Kinases Are Recruited to Sites of Adhesive Contact
19
Abl Family Kinases Interact with Multiple Proteins upon Integrin Engagement
20
Abl and Cell Death
26
Abl in GenotoxinInduced Cell Death
27
Abl in TNFInduced Cell Death
31
Death Effectors Regulated by Abl
34
Oncogenic BCRABL in Cell Death Regulation
36
Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases
48
Basic Anatomy
49
Mechanisms by Which Abl Family Kinases Regulate Cytoskeletal Structure
54
Abl Family Kinases Also Regulate Actin Structure Independently of Rho GTPases
57
Abl Family Kinases Interact Directly with FActin and Microtubules
60
TELABL and TELARG
86
Abl Family Kinases in Mammalian Development
93
Tissue Expression Patterns of Abl and Arg
95
Lymphocyte Development in abl and ablmımı Mice
96
Neuronal Development in abl and arg Mice
99
Bone Development in abl Mice
101
Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity
105
Abelson Tyrosine Kinases and Axon Guidance
106
Abls Role in Dendrites and Synapses
116
Index
123
Copyright

Other editions - View all

Common terms and phrases

Bibliographic information